HARS2 Antibody – Rabbit Polyclonal

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

HARS2: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter. [provided by RefSeq, Jul 2008]

Protein type: Aminoacyl-tRNA synthetase; EC 6.1.1.21; Ligase; Mitochondrial; Translation; Translation regulation

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: ATP binding; histidine-tRNA ligase activity; protein binding; protein homodimerization activity; RNA binding

Biological Process: histidyl-tRNA aminoacylation; mitochondrial translation; translation; tRNA aminoacylation for protein translation

Disease: Perrault Syndrome 2