GPSM1 Antibody – Rabbit Polyclonal

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Function: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Ref.6 Ref.7

Subunit structure: Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1

By similarity. Interacts with INSC/inscuteable and FRMPD1. Ref.8 Ref.9

Subcellular location: Cytoplasm › cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side Ref.7 Ref.9.

Tissue specificity: Expressed in intestinal cells. Ref.7

Domain: The GoLoco domains mediate interaction with G(i/o) alpha

By similarity. The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.

Post-translational modification: Phosphorylation regulates interaction with G(i/o) alpha

By similarity.

Sequence similarities: Belongs to the GPSM family.Contains 4 GoLoco domains.Contains 9 TPR repeats.

Sequence caution: The sequence AAH09979.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH17353.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAB55951.1 differs from that shown. Reason: Frameshift at position 657. The sequence CAI19339.1 differs from that shown. Reason: Erroneous gene model prediction.