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CELF3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3220565

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CELF3, Polyclonal Antibody
Full Product Name
CELF3 Antibody - middle region
Product Gene Name
anti-CELF3 antibody
Product Synonym Gene Name
CAGH4; ERDA4; ETR-1; TNRC4; BRUNOL1;
Immunogen Sequence
Synthetic peptide located within the following region: PTGQPAPDAL YPNGVHPYPA QSPAAPVDPL QQAYAGMQHY TAAYPAAYSL
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 23% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
CELF3 peptide (MBS3245367) is used for blocking the activity of CELF3 antibody (MBS3220565)
Molecular Weight
51 kDa
OMIM
612678
3D Structure
ModBase 3D Structure for Q5SZQ8
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CELF3

Product Categories/Family for anti-CELF3 antibody

Polyclonal; Transcription Factor; RNA Binding Proteins; Neurobiology; Transcription Regulation; Cell Biology
Applications Tested/Suitable for anti-CELF3 antibody
Western Blot (WB)

Western Blot (WB) of anti-CELF3 antibody

Host: Rabbit
Target Name: CELF3
Sample Tissue: Liver Tumor lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-CELF3 Polyclonal Antibody – Cat# MBS3220565

Other Notes

Small volumes of anti-CELF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CELF3 purchase

MBS3220565 is an antibody targeting CELF3. Also known as CELF3 Antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CELF3. It may not necessarily be applicable to this product.

NCBI GI #
71164894
NCBI GeneID
11189
NCBI Accession #
NP_001166120.1
UniProt Primary Accession #
Q5SZQ8
UniProt Related Accession #
Q5SZQ8
GenBank Nucleotide #
NM_001172649.3
NCBI Official Full Name
CUGBP Elav-like family member 3 isoform 1
NCBI Official Synonym Full Names
CUGBP Elav-like family member 3
NCBI Official Symbol
CELF3
NCBI Official Synonym Symbols
CAGH4; ERDA4; ETR-1; TNRC4; BRUNOL1
UniProt Protein Name
CUGBP Elav-like family member 3
UniProt Synonym Protein Names
Bruno-like protein 1; CAG repeat protein 4; CUG-BP- and ETR-3-like factor 3; ELAV-type RNA-binding protein 1; ETR-1; Expanded repeat domain protein CAG/CTG 4; RNA-binding protein BRUNOL-1; Trinucleotide repeat-containing gene 4 protein
Protein Family
CUGBP Elav-like family
UniProt Gene Name
CELF3
UniProt Synonym Gene Names
BRUNOL1; CAGH4; ERDA4; TNRC4; CELF-3; ETR-1
UniProt Entry Name
CELF3_HUMAN
NCBI Protein Information
CUGBP Elav-like family member 3

UniProt Comments for CELF3

TNRC4: RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Belongs to the CELF/BRUNOL family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; nucleus

Molecular Function: mRNA binding; RNA binding; nucleotide binding

Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of nuclear mRNA splicing, via spliceosome; sperm motility; RNA splicing; spermatogenesis; regulation of alternative nuclear mRNA splicing, via spliceosome
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Research Articles on CELF3

1. Gomafu indirectly modulates the function of the splicing factors SF1 and Celf3 by sequestering these proteins into separate nuclear bodies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CELF3 antibody

 Disease Name  Pubmed Publications
 Nervous System Neoplasms Antibodies  >1 publications with CELF3 and Nervous System Neoplasms

Organs/Tissues associated with anti-CELF3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with CELF3 and Brain
 Testis Antibodies  >1 publications with CELF3 and Testis
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