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NCK2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3220826

This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NCK2, Polyclonal Antibody
Full Product Name
NCK2 Antibody - middle region
Product Gene Name
anti-NCK2 antibody
Product Synonym Gene Name
GRB4; NCKbeta;
Immunogen Sequence
Synthetic peptide located within the following region: LGLGKTRRKT SARDASPTPS TDAEYPANGS GADRIYDLNI PAFVKFAYVA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
NCK2 peptide (MBS3245623) is used for blocking the activity of NCK2 antibody (MBS3220826)
Molecular Weight
41 kDa
OMIM
604930
3D Structure
ModBase 3D Structure for O43639
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human NCK2

Product Categories/Family for anti-NCK2 antibody

Polyclonal; Cell Biology
Applications Tested/Suitable for anti-NCK2 antibody
Western Blot (WB)

Western Blot (WB) of anti-NCK2 antibody

Host: Rabbit
Target Name: NCK2
Sample Tissue: PANC1 Whole Cell lysates
Antibody Dilution: 1.0ug/ml
Rabbit Anti-NCK2 Polyclonal Antibody – Cat# MBS3220826

Other Notes

Small volumes of anti-NCK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NCK2 purchase

MBS3220826 is an antibody targeting NCK2. Also known as NCK2 Antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NCK2. It may not necessarily be applicable to this product.

NCBI GI #
52630425
NCBI GeneID
8440
NCBI Accession #
NP_001004720.1
UniProt Primary Accession #
O43639
UniProt Related Accession #
O43639
GenBank Nucleotide #
NM_001004720.2
NCBI Official Full Name
cytoplasmic protein NCK2 isoform A
NCBI Official Synonym Full Names
NCK adaptor protein 2
NCBI Official Symbol
NCK2
NCBI Official Synonym Symbols
GRB4; NCKbeta
UniProt Protein Name
Cytoplasmic protein NCK2
UniProt Synonym Protein Names
Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta
Protein Family
Cytoplasmic protein
UniProt Gene Name
NCK2
UniProt Synonym Gene Names
GRB4; Nck-2
UniProt Entry Name
NCK2_HUMAN
NCBI Protein Information
cytoplasmic protein NCK2

UniProt Comments for NCK2

NCK2: Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: endoplasmic reticulum; cytoplasm; vesicle membrane; cytosol

Molecular Function: protein binding; receptor signaling complex scaffold activity; SH3/SH2 adaptor activity; cytoskeletal adaptor activity

Biological Process: lamellipodium biogenesis; epidermal growth factor receptor signaling pathway; axon guidance; cell migration; T cell activation; positive regulation of signal transduction; regulation of epidermal growth factor receptor activity; negative regulation of peptidyl-serine phosphorylation; signal complex assembly; actin filament organization; signal transduction; regulation of translation; negative regulation of cell proliferation; positive regulation of actin filament polymerization; ephrin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; vascular endothelial growth factor receptor signaling pathway
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Research Articles on NCK2

1. This study provides evidence of a possible role of NCK2 as biomarker of ovarian cancer progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NCK2 antibody

 Reference Product  PubMed Publications
 LIMS1 antibody  >5 publications with NCK2 and LIMS1
 PAK1 antibody  >3 publications with NCK2 and PAK1
 PDGFRB antibody  >3 publications with NCK2 and PDGFRB
 NTRK2 antibody  >1 publications with NCK2 and NTRK2
 HNRNPK antibody  >1 publications with NCK2 and HNRNPK
 FGFR1 antibody  >1 publications with NCK2 and FGFR1
 EGFR antibody  >1 publications with NCK2 and EGFR
 DOK1 antibody  >1 publications with NCK2 and DOK1
 DDR1 antibody  >1 publications with NCK2 and DDR1
 CD3E antibody  >1 publications with NCK2 and CD3E

Pathways associated with anti-NCK2 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Rac Pathway antibodies  Activation Of Rac Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Ephrin B Reverse Signaling Pathway antibodies  Ephrin B Reverse Signaling Pathway Diagram

Diseases associated with anti-NCK2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with NCK2 and Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with NCK2 and Neoplasm Metastasis
 Vascular Diseases Antibodies  >1 publications with NCK2 and Vascular Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with NCK2 and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >1 publications with NCK2 and Heart Diseases
 Hypertrophy Antibodies  >1 publications with NCK2 and Hypertrophy

Organs/Tissues associated with anti-NCK2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with NCK2 and Brain
 Skin Antibodies  >4 publications with NCK2 and Skin
 Embryonic Tissue Antibodies  >2 publications with NCK2 and Embryonic Tissue
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