• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

YME1L1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3220961

The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in… More details

$490 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
YME1L1, Polyclonal Antibody
Full Product Name
YME1L1 Antibody - middle region
Product Gene Name
anti-YME1L1 antibody
Product Synonym Gene Name
FTSH; MEG4; PAMP; YME1L
Immunogen Sequence
Synthetic peptide located within the following region: LENLVNQAAL KAAVDGKEMV TMKELEFSKD KILMGPERRS VEIDNKNKTI
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
YME1L1 peptide (MBS3245755) is used for blocking the activity of YME1L1 antibody (MBS3220961)
Molecular Weight
85 kDa
OMIM
607472
3D Structure
ModBase 3D Structure for Q96TA2
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human YME1L1

Product Categories/Family for anti-YME1L1 antibody

Polyclonal; Mitochondria; Disease Related
Applications Tested/Suitable for anti-YME1L1 antibody
Western Blot (WB)

Western Blot (WB) of anti-YME1L1 antibody

Host: Rabbit
Target Name: YME1L1
Sample Tissue: Human Esophagus Tumor lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-YME1L1 Polyclonal Antibody – Cat# MBS3220961

Other Notes

Small volumes of anti-YME1L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for YME1L1 purchase

MBS3220961 is an antibody targeting YME1L1. Also known as YME1L1 Antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for YME1L1. It may not necessarily be applicable to this product.

NCBI GI #
359718987
NCBI GeneID
10730
NCBI Accession #
NP_001240795.1
UniProt Primary Accession #
Q96TA2
UniProt Related Accession #
Q96TA2
GenBank Nucleotide #
NM_001253866.1
NCBI Official Full Name
ATP-dependent zinc metalloprotease YME1L1 isoform 4
NCBI Official Synonym Full Names
YME1 like 1 ATPase
NCBI Official Symbol
YME1L1
NCBI Official Synonym Symbols
FTSH; MEG4; PAMP; OPA11; YME1L
UniProt Protein Name
ATP-dependent zinc metalloprotease YME1L1
UniProt Synonym Protein Names
ATP-dependent metalloprotease FtsH1; Meg-4; Presenilin-associated metalloprotease; PAMP; YME1-like protein 1
Protein Family
ATP-dependent zinc metalloprotease
UniProt Gene Name
YME1L1
UniProt Synonym Gene Names
FTSH1; YME1L; PAMP
UniProt Entry Name
YMEL1_HUMAN
NCBI Protein Information
ATP-dependent zinc metalloprotease YME1L1

UniProt Comments for YME1L1

YME1L1: Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Protease; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 10p14

Cellular Component: integral to membrane; membrane; mitochondrial inner membrane; mitochondrion; nucleoplasm

Molecular Function: ATP binding; ATP-dependent peptidase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity

Biological Process: cell proliferation; misfolded or incompletely synthesized protein catabolic process; mitochondrion organization and biogenesis
Show more

Research Articles on YME1L1

1. Data show that engineered YME1L protease discriminates between degradation signals by amino acid composition, implying the use of sequence-specific signals in mitochondrial proteostasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-YME1L1 antibody

 Disease Name  Pubmed Publications
 Paralysis Antibodies  >1 publications with YME1L1 and Paralysis
 Central Nervous System Diseases Antibodies  >1 publications with YME1L1 and Central Nervous System Diseases
 Chromosome Aberrations Antibodies  >1 publications with YME1L1 and Chromosome Aberrations
 Atrophy Antibodies  >1 publications with YME1L1 and Atrophy

Organs/Tissues associated with anti-YME1L1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with YME1L1 and Brain
 Heart Antibodies  >1 publications with YME1L1 and Heart
 Pancreas Antibodies  >1 publications with YME1L1 and Pancreas
 Muscle Antibodies  >1 publications with YME1L1 and Muscle
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000