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ITGB6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3221832

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ITGB6, Polyclonal Antibody
Full Product Name
ITGB6 Antibody - N-terminal region
Product Gene Name
anti-ITGB6 antibody
Product Synonym Gene Name
AI1H
Immunogen Sequence
Synthetic peptide located within the following region: VEILKNKPLS VGRQKNSSDI VQIAPQSLIL KLRPGGAQTL QVHVRQTEDY
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
ITGB6 peptide (MBS3246558) is used for blocking the activity of ITGB6 antibody (MBS3221832)
Molecular Weight
86 kDa
OMIM
147558
3D Structure
ModBase 3D Structure for P18564
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human ITGB6

Product Categories/Family for anti-ITGB6 antibody

Polyclonal; Signal Proteins; Cell Adhesion; Growth Factors & Hormones; Membrane Protein
Applications Tested/Suitable for anti-ITGB6 antibody
Western Blot (WB)

Western Blot (WB) of anti-ITGB6 antibody

Host: Rabbit
Target Name: ITGB6
Sample Tissue: Human Lung Tumor lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-ITGB6 Polyclonal Antibody – Cat# MBS3221832

Other Notes

Small volumes of anti-ITGB6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITGB6 purchase

MBS3221832 is an antibody targeting ITGB6. Also known as ITGB6 Antibody - N-terminal region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ITGB6. It may not necessarily be applicable to this product.

NCBI GI #
9625002
NCBI GeneID
3694
NCBI Accession #
NP_000879.2
UniProt Primary Accession #
P18564
UniProt Related Accession #
P18564
GenBank Nucleotide #
NM_000888.4
NCBI Official Full Name
integrin beta-6 isoform a
NCBI Official Synonym Full Names
integrin subunit beta 6
NCBI Official Symbol
ITGB6
NCBI Official Synonym Symbols
AI1H
UniProt Protein Name
Integrin beta-6
Protein Family
Integrin
UniProt Gene Name
ITGB6
UniProt Entry Name
ITB6_HUMAN
NCBI Protein Information
integrin beta-6

UniProt Comments for ITGB6

ITGB6: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Belongs to the integrin beta chain family.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: plasma membrane; integrin complex; receptor complex; external side of plasma membrane

Molecular Function: viral receptor activity; integrin binding

Biological Process: integrin-mediated signaling pathway; entry of virus into host cell; extracellular matrix organization and biogenesis; multicellular organismal development; cell-matrix adhesion; inflammatory response; cell adhesion

Disease: Amelogenesis Imperfecta, Type Ih
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Research Articles on ITGB6

1. these findings demonstrate that JunB and CBP-mediated histone hyperacetylation are responsible for TGF-beta1 induced ITGB6 transcription in oral squamous cell carcinoma (OSCC) cells, suggesting that epigenetic mechanisms are responsible for the active transcription expression of ITGB6 induced by TGF-beta1 in OSCC cells.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ITGB6 antibody

 Reference Product  PubMed Publications
 ITGAV antibody  >5 publications with ITGB6 and ITGAV
 FBN1 antibody  >1 publications with ITGB6 and FBN1

Pathways associated with anti-ITGB6 antibody

 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram

Diseases associated with anti-ITGB6 antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >9 publications with ITGB6 and Lung Diseases
 Neoplasms Antibodies  >5 publications with ITGB6 and Neoplasms
 Inflammation Antibodies  >5 publications with ITGB6 and Inflammation
 Fibrosis Antibodies  >5 publications with ITGB6 and Fibrosis
 Pulmonary Emphysema Antibodies  >4 publications with ITGB6 and Pulmonary Emphysema
 Disease Models, Animal Antibodies  >3 publications with ITGB6 and Disease Models, Animal
 Congenital Abnormalities Antibodies  >3 publications with ITGB6 and Congenital Abnormalities
 Nervous System Diseases Antibodies  >2 publications with ITGB6 and Nervous System Diseases
 Kidney Diseases Antibodies  >1 publications with ITGB6 and Kidney Diseases
 Breast Neoplasms Antibodies  >1 publications with ITGB6 and Breast Neoplasms

Organs/Tissues associated with anti-ITGB6 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with ITGB6 and Lung
 Mouth Antibodies  >4 publications with ITGB6 and Mouth
 Brain Antibodies  >4 publications with ITGB6 and Brain
 Skin Antibodies  >3 publications with ITGB6 and Skin
 Kidney Antibodies  >2 publications with ITGB6 and Kidney
 Nerve Antibodies  >1 publications with ITGB6 and Nerve
 Heart Antibodies  >1 publications with ITGB6 and Heart
 Prostate Antibodies  >1 publications with ITGB6 and Prostate
 Placenta Antibodies  >1 publications with ITGB6 and Placenta
 Uterus Antibodies  >1 publications with ITGB6 and Uterus
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