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NASP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3222402

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NASP, Polyclonal Antibody
Full Product Name
NASP Antibody - middle region
Product Gene Name
anti-NASP antibody
Product Synonym Gene Name
HMDRA1; FLB7527; PRO1999
Immunogen Sequence
Synthetic peptide located within the following region: ETEGSEEDDK ENDKTEEMPN DSVLENKSLQ ENEEEEIGNL ELAWDMLDLA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
NASP peptide (MBS3247074) is used for blocking the activity of NASP antibody (MBS3222402)
Molecular Weight
86 kDa
OMIM
603185
3D Structure
ModBase 3D Structure for P49321
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human NASP

Product Categories/Family for anti-NASP antibody

Polyclonal; Chromatin & Nuclear Signaling; Developmental Biology; DNA/RNA/Protein Interactions; Meiosis/Mitosis/Cell Cycle; Tissue Specific & Cell Marker
Applications Tested/Suitable for anti-NASP antibody
Western Blot (WB)

Western Blot (WB) of anti-NASP antibody

Host: Rabbit
Target Name: NASP
Sample Tissue: Human 786-0 Whole Cell lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-NASP Polyclonal Antibody – Cat# MBS3222402

Other Notes

Small volumes of anti-NASP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NASP purchase

MBS3222402 is an antibody targeting NASP. Also known as NASP Antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NASP. It may not necessarily be applicable to this product.

NCBI GI #
304434531
NCBI GeneID
4678
NCBI Accession #
NP_001182122.1
UniProt Primary Accession #
P49321
UniProt Related Accession #
P49321
GenBank Nucleotide #
NM_001195193.1
NCBI Official Full Name
nuclear autoantigenic sperm protein isoform 4
NCBI Official Synonym Full Names
nuclear autoantigenic sperm protein
NCBI Official Symbol
NASP
NCBI Official Synonym Symbols
HMDRA1; FLB7527; PRO1999
UniProt Protein Name
Nuclear autoantigenic sperm protein
Protein Family
Nuclear autoantigenic sperm protein
UniProt Gene Name
NASP
UniProt Synonym Gene Names
NASP
UniProt Entry Name
NASP_HUMAN
NCBI Protein Information
nuclear autoantigenic sperm protein

UniProt Comments for NASP

NASP: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. Belongs to the NASP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: nucleoplasm; protein complex; cytoplasm; nuclear chromatin; nucleus

Molecular Function: histone binding; Hsp90 protein binding

Biological Process: cell proliferation; blastocyst development; protein transport; DNA replication-independent nucleosome assembly; histone exchange; cell cycle; DNA replication; DNA replication-dependent nucleosome assembly
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Research Articles on NASP

1. NASP is targeted by miR-29c in gastric cancer cells. miR-29c can decrease NASP expression and the effects observed following miR-29c overexpression are partially due to NASP depletion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-NASP antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with NASP and Neoplasms
 Breast Neoplasms Antibodies  >2 publications with NASP and Breast Neoplasms
 Infertility, Male Antibodies  >2 publications with NASP and Infertility, Male
 Ovarian Neoplasms Antibodies  >2 publications with NASP and Ovarian Neoplasms
 Skin Neoplasms Antibodies  >2 publications with NASP and Skin Neoplasms
 Carcinoma Antibodies  >2 publications with NASP and Carcinoma
 Prostatic Neoplasms Antibodies  >1 publications with NASP and Prostatic Neoplasms
 Fatty Liver Antibodies  >1 publications with NASP and Fatty Liver
 Liver Diseases Antibodies  >1 publications with NASP and Liver Diseases
 Fibrosis Antibodies  >1 publications with NASP and Fibrosis

Organs/Tissues associated with anti-NASP antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >15 publications with NASP and Testis
 Blood Antibodies  >11 publications with NASP and Blood
 Brain Antibodies  >7 publications with NASP and Brain
 Skin Antibodies  >5 publications with NASP and Skin
 Liver Antibodies  >3 publications with NASP and Liver
 Lymph Antibodies  >3 publications with NASP and Lymph
 Lymph Node Antibodies  >3 publications with NASP and Lymph Node
 Embryonic Tissue Antibodies  >3 publications with NASP and Embryonic Tissue
 Kidney Antibodies  >1 publications with NASP and Kidney
 Lung Antibodies  >1 publications with NASP and Lung
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