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ITPKA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3222628

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ITPKA, Polyclonal Antibody
Full Product Name
ITPKA Antibody - C-terminal region
Product Gene Name
anti-ITPKA antibody
Product Synonym Gene Name
IP3KA; IP3-3KA
Immunogen Sequence
Synthetic peptide located within the following region: GVWLIDFGKT TPLPDGQILD HRRPWEEGNR EDGYLLGLDN LIGILASLAE
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
ITPKA peptide (MBS3247296) is used for blocking the activity of ITPKA antibody (MBS3222628)
Molecular Weight
50 kDa
OMIM
147521
3D Structure
ModBase 3D Structure for P23677
Immunogen
The immunogen is a synthetic peptide directed towards the C region of human ITPKA

Product Categories/Family for anti-ITPKA antibody

Polyclonal; Signal Proteins; Signaling Intermediate
Applications Tested/Suitable for anti-ITPKA antibody
Western Blot (WB)

Western Blot (WB) of anti-ITPKA antibody

Host: Rabbit
Target Name: ITPKA
Sample Tissue: Human LN18 Whole Cell lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-ITPKA Polyclonal Antibody – Cat# MBS3222628

Other Notes

Small volumes of anti-ITPKA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITPKA purchase

MBS3222628 is an antibody targeting ITPKA. Also known as ITPKA Antibody - C-terminal region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ITPKA. It may not necessarily be applicable to this product.

NCBI GI #
4504789
NCBI GeneID
3706
NCBI Accession #
NP_002211.1
UniProt Primary Accession #
P23677
UniProt Related Accession #
P23677
GenBank Nucleotide #
NM_002220.2
NCBI Official Full Name
inositol-trisphosphate 3-kinase A
NCBI Official Synonym Full Names
inositol-trisphosphate 3-kinase A
NCBI Official Symbol
ITPKA
NCBI Official Synonym Symbols
IP3KA; IP3-3KA
UniProt Protein Name
Inositol-trisphosphate 3-kinase A
UniProt Synonym Protein Names
Inositol 1,4,5-trisphosphate 3-kinase A
Protein Family
Inositol-trisphosphate 3-kinase
UniProt Gene Name
ITPKA
UniProt Synonym Gene Names
IP3 3-kinase A; IP3K A
UniProt Entry Name
IP3KA_HUMAN
NCBI Protein Information
inositol-trisphosphate 3-kinase A

UniProt Comments for ITPKA

ITPKA: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

Protein type: Kinase, lipid; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: dendritic spine; cytosol

Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; Rac GTPase binding; inositol trisphosphate 3-kinase activity; ATP binding

Biological Process: inositol phosphate metabolic process; inositol metabolic process; regulation of synaptic plasticity; signal transduction; actin cytoskeleton organization and biogenesis; protein amino acid phosphorylation
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Research Articles on ITPKA

1. ITPKA is a potential oncogene that it is overexpressed in most tumors, and its overexpression promotes tumorigenesis; ITPKA gene body methylation regulates its expression and serves as a novel and potential biomarker for early cancer detection

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ITPKA antibody

 Products by Pathway  Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram

Diseases associated with anti-ITPKA antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with ITPKA and Neoplasms
 Disease Models, Animal Antibodies  >1 publications with ITPKA and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >1 publications with ITPKA and Neoplasms, Experimental
 Weight Loss Antibodies  >1 publications with ITPKA and Weight Loss

Organs/Tissues associated with anti-ITPKA antibody

 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >2 publications with ITPKA and Ovary
 Lung Antibodies  >2 publications with ITPKA and Lung
 Brain Antibodies  >2 publications with ITPKA and Brain
 Testis Antibodies  >1 publications with ITPKA and Testis
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