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ITGB7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3222672

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ITGB7, Polyclonal Antibody
Full Product Name
ITGB7 Antibody - middle region
Product Gene Name
anti-ITGB7 antibody
Immunogen Sequence
Synthetic peptide located within the following region: LEHSSLPPGV HISYESQCEG PEKREGKAED RGQCNHVRIN QTVTFWVSLQ
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
ITGB7 peptide (MBS3247339) is used for blocking the activity of ITGB7 antibody (MBS3222672)
Molecular Weight
87 kDa
OMIM
M68892 mRNA
3D Structure
ModBase 3D Structure for P26010
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human ITGB7

Product Categories/Family for anti-ITGB7 antibody

Polyclonal; Signal Proteins; Cell Adhesion; Membrane Protein
Applications Tested/Suitable for anti-ITGB7 antibody
Western Blot (WB)

Western Blot (WB) of anti-ITGB7 antibody

Host: Rabbit
Target Name: ITGB7
Sample Tissue: Human A172 Whole Cell lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-ITGB7 Polyclonal Antibody – Cat# MBS3222672

Other Notes

Small volumes of anti-ITGB7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITGB7 purchase

MBS3222672 is an antibody targeting ITGB7. Also known as ITGB7 Antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ITGB7. It may not necessarily be applicable to this product.

NCBI GI #
4504777
NCBI GeneID
3695
NCBI Accession #
NP_000880.1
UniProt Primary Accession #
P26010
UniProt Related Accession #
P26010
GenBank Nucleotide #
NM_000889.2
NCBI Official Full Name
integrin beta-7
NCBI Official Synonym Full Names
integrin subunit beta 7
NCBI Official Symbol
ITGB7
UniProt Protein Name
Integrin beta-7
UniProt Synonym Protein Names
Gut homing receptor beta subunit
Protein Family
Integrin
UniProt Gene Name
ITGB7
NCBI Protein Information
integrin beta-7

UniProt Comments for ITGB7

ITGB7: integrin alpha-4/beta-7 (Peyer's patches-specific homing receptor lpam-1) is expected to play a role in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM 1. Integrin alpha-e/beta-7 (HML-1) is a receptor for e-cadherin. Two alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cell surface; integrin complex; membrane; plasma membrane; receptor complex

Molecular Function: cell adhesion molecule binding; protein binding

Biological Process: cell adhesion; cell-matrix adhesion; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte tethering or rolling; receptor clustering; regulation of immune response
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Research Articles on ITGB7

1. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ITGB7 antibody

 Reference Product  PubMed Publications
 ITGA4 antibody  >3 publications with ITGB7 and ITGA4
 ITGA9 antibody  >2 publications with ITGB7 and ITGA9
 ITGAE antibody  >1 publications with ITGB7 and ITGAE

Pathways associated with anti-ITGB7 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 E-cadherin Signaling In The Nascent Adherens Junction Pathway antibodies  E-cadherin Signaling In The Nascent Adherens Junction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram

Diseases associated with anti-ITGB7 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3 publications with ITGB7 and Cardiovascular Diseases
 Inflammation Antibodies  >3 publications with ITGB7 and Inflammation
 Lung Diseases Antibodies  >2 publications with ITGB7 and Lung Diseases
 Disease Models, Animal Antibodies  >1 publications with ITGB7 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >1 publications with ITGB7 and Neoplasm Metastasis
 Necrosis Antibodies  >1 publications with ITGB7 and Necrosis

Organs/Tissues associated with anti-ITGB7 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with ITGB7 and Blood
 Lymph Antibodies  >3 publications with ITGB7 and Lymph
 Lymph Node Antibodies  >3 publications with ITGB7 and Lymph Node
 Uterus Antibodies  >2 publications with ITGB7 and Uterus
 Bone Marrow Antibodies  >2 publications with ITGB7 and Bone Marrow
 Intestine Antibodies  >2 publications with ITGB7 and Intestine
 Placenta Antibodies  >1 publications with ITGB7 and Placenta
 Lung Antibodies  >1 publications with ITGB7 and Lung
 Embryonic Tissue Antibodies  >1 publications with ITGB7 and Embryonic Tissue
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