SGO1 Antibody – Rabbit Polyclonal

SGO1: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Belongs to the shugoshin family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 3p24.3

Cellular Component: kinetochore; nucleoplasm; spindle pole; centrosome; cytoplasm; cytosol; condensed nuclear chromosome, pericentric region; chromosome, pericentric region

Molecular Function: protein binding; kinase binding

Biological Process: mitosis; cell division; mitotic cell cycle; attachment of spindle microtubules to kinetochore; centriole-centriole cohesion; meiotic chromosome segregation; chromosome segregation

Disease: Chronic Atrial And Intestinal Dysrhythmia