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RFC3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3223303

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RFC3, Polyclonal Antibody
Full Product Name
RFC3 Antibody - middle region
Product Gene Name
anti-RFC3 antibody
Product Synonym Gene Name
RFC38
Immunogen Sequence
Synthetic peptide located within the following region: TPSKKKIEIS TIASNYHLEV NPSDAGNSDR VVIQEMLKTV AQSQQLETNS
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
RFC3 peptide (MBS3247946) is used for blocking the activity of RFC3 antibody (MBS3223303)
Molecular Weight
35 kDa
OMIM
600405
3D Structure
ModBase 3D Structure for P40938
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human RFC3

Product Categories/Family for anti-RFC3 antibody

Polyclonal; Cell Cycle Proteins; Cell Biology; Chromatin & Nuclear Signaling; Signal Transduction
Applications Tested/Suitable for anti-RFC3 antibody
Western Blot (WB)

Western Blot (WB) of anti-RFC3 antibody

Host: Rabbit
Target Name: RFC3
Sample Tissue: Human A549 Whole Cell lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-RFC3 Polyclonal Antibody – Cat# MBS3223303

Other Notes

Small volumes of anti-RFC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RFC3 purchase

MBS3223303 is an antibody targeting RFC3. Also known as RFC3 Antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RFC3. It may not necessarily be applicable to this product.

NCBI GI #
4506489
NCBI GeneID
5983
NCBI Accession #
NP_002906.1
UniProt Primary Accession #
P40938
UniProt Related Accession #
P40938
GenBank Nucleotide #
NM_002915.3
NCBI Official Full Name
replication factor C subunit 3 isoform 1
NCBI Official Synonym Full Names
replication factor C subunit 3
NCBI Official Symbol
RFC3
NCBI Official Synonym Symbols
RFC38
UniProt Protein Name
Replication factor C subunit 3
UniProt Synonym Protein Names
Activator 1 38 kDa subunit; A1 38 kDa subunit; Activator 1 subunit 3; Replication factor C 38 kDa subunit; RF-C 38 kDa subunit; RFC38
Protein Family
Probable replication factor
UniProt Gene Name
RFC3
UniProt Synonym Gene Names
A1 38 kDa subunit; RF-C 38 kDa subunit; RFC38
UniProt Entry Name
RFC3_HUMAN
NCBI Protein Information
replication factor C subunit 3

UniProt Comments for RFC3

RFC3: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Belongs to the activator 1 small subunits family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 13q13.2

Cellular Component: nucleoplasm; DNA replication factor C complex; nucleus

Molecular Function: protein binding; DNA binding; ATPase activity; DNA clamp loader activity

Biological Process: telomere maintenance via semi-conservative replication; DNA synthesis during DNA repair; response to organophosphorus; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; telomere maintenance via recombination; mitotic cell cycle; nucleotide-excision repair, DNA gap filling; DNA strand elongation during DNA replication; DNA repair; DNA replication; telomere maintenance
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Research Articles on RFC3

1. The expression level of RFC3 was markedly upregulated in the HCC tissues and cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RFC3 antibody

 Reference Product  PubMed Publications
 RFC4 antibody  >27 publications with RFC3 and RFC4
 RFC2 antibody  >26 publications with RFC3 and RFC2
 PCNA antibody  >26 publications with RFC3 and PCNA
 RFC5 antibody  >18 publications with RFC3 and RFC5
 RFC1 antibody  >11 publications with RFC3 and RFC1
 RAD17 antibody  >6 publications with RFC3 and RAD17
 POLA1 antibody  >1 publications with RFC3 and POLA1

Pathways associated with anti-RFC3 antibody

 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram

Diseases associated with anti-RFC3 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >2 publications with RFC3 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >2 publications with RFC3 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >1 publications with RFC3 and Ovarian Neoplasms
 Nervous System Diseases Antibodies  >1 publications with RFC3 and Nervous System Diseases
 Disease Models, Animal Antibodies  >1 publications with RFC3 and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with RFC3 and Breast Neoplasms

Organs/Tissues associated with anti-RFC3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with RFC3 and Blood
 Cervix Antibodies  >2 publications with RFC3 and Cervix
 Uterus Antibodies  >2 publications with RFC3 and Uterus
 Thyroid Antibodies  >1 publications with RFC3 and Thyroid
 Stomach Antibodies  >1 publications with RFC3 and Stomach
 Ovary Antibodies  >1 publications with RFC3 and Ovary
 Mammary Gland Antibodies  >1 publications with RFC3 and Mammary Gland
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