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SORBS2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3223428

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the… More details

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Product Overview

Online Datasheet in PDF
Product Name
SORBS2, Polyclonal Antibody
Full Product Name
SORBS2 Antibody - middle region
Product Gene Name
anti-SORBS2 antibody
Product Synonym Gene Name
ARGBP2; PRO0618
Immunogen Sequence
Synthetic peptide located within the following region: PPHVPPPVPP LRPRDRSSTE KHDWDPPDRK VDTRKFRSEP RSIFEYEPGK
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
SORBS2 peptide (MBS3248064) is used for blocking the activity of SORBS2 antibody (MBS3223428)
Molecular Weight
80 kDa
3D Structure
ModBase 3D Structure for O94875
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human SORBS2

Product Categories/Family for anti-SORBS2 antibody

Polyclonal; Signaling Intermediate; Cardiovascular; E3 & Ubiquitin
Applications Tested/Suitable for anti-SORBS2 antibody
Western Blot (WB)

Western Blot (WB) of anti-SORBS2 antibody

Host: Rabbit
Target Name: SORBS2
Sample Tissue: Human A549 Whole Cell lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-SORBS2 Polyclonal Antibody – Cat# MBS3223428

Other Notes

Small volumes of anti-SORBS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SORBS2 purchase

MBS3223428 is an antibody targeting SORBS2. Also known as SORBS2 Antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SORBS2. It may not necessarily be applicable to this product.

NCBI GI #
224586844
NCBI GeneID
8470
NCBI Accession #
NP_001139142.1
UniProt Primary Accession #
O94875
UniProt Related Accession #
O94875
GenBank Nucleotide #
NM_001145670.1
NCBI Official Full Name
sorbin and SH3 domain-containing protein 2 isoform 3
NCBI Official Synonym Full Names
sorbin and SH3 domain containing 2
NCBI Official Symbol
SORBS2
NCBI Official Synonym Symbols
ARGBP2; PRO0618
UniProt Protein Name
Sorbin and SH3 domain-containing protein 2
UniProt Synonym Protein Names
Arg/Abl-interacting protein 2; ArgBP2; Sorbin
Protein Family
Sorbin and SH3 domain-containing protein
UniProt Gene Name
SORBS2
UniProt Synonym Gene Names
ARGBP2; KIAA0777; ArgBP2
UniProt Entry Name
SRBS2_HUMAN
NCBI Protein Information
sorbin and SH3 domain-containing protein 2

UniProt Comments for SORBS2

ArgBP2: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: perinuclear region of cytoplasm; plasma membrane; nucleus; Z disc; actin cytoskeleton

Molecular Function: protein domain specific binding; protein binding; structural constituent of cytoskeleton; structural constituent of muscle; metal ion binding; cytoskeletal adaptor activity

Biological Process: cell migration; actin filament organization; cell adhesion
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Research Articles on SORBS2

1. By enhancing the stability of gene transcripts, SORBS2 suppresses ovarian cancer invasiveness and affects monocyte to myeloid-derived suppressor cell and M2-like macrophage polarization, eliciting a tumor-suppressive immune microenvironment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SORBS2 antibody

 Reference Product  PubMed Publications
 CBL antibody  >6 publications with SORBS2 and CBL
 WASF1 antibody  >2 publications with SORBS2 and WASF1
 PTK2B antibody  >1 publications with SORBS2 and PTK2B

Diseases associated with anti-SORBS2 antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >2 publications with SORBS2 and Fibrosis
 Neoplasm Metastasis Antibodies  >2 publications with SORBS2 and Neoplasm Metastasis
 Hypertrophy Antibodies  >2 publications with SORBS2 and Hypertrophy
 Cell Transformation, Neoplastic Antibodies  >1 publications with SORBS2 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >1 publications with SORBS2 and Nervous System Diseases
 Proteinuria Antibodies  >1 publications with SORBS2 and Proteinuria
 Kidney Diseases Antibodies  >1 publications with SORBS2 and Kidney Diseases

Organs/Tissues associated with anti-SORBS2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >11 publications with SORBS2 and Muscle
 Lymph Antibodies  >1 publications with SORBS2 and Lymph
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