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APPL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3223476

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A,… More details

$490 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
APPL1, Polyclonal Antibody
Full Product Name
APPL1 Antibody - C-terminal region
Product Gene Name
anti-APPL1 antibody
Product Synonym Gene Name
APPL; DIP13alpha
Immunogen Sequence
Synthetic peptide located within the following region: EKDLEEQSRL IAASSRPNQA SSEGQFVVLS SSQSEESDLG EGGKKRESEA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
APPL1 peptide (MBS3248109) is used for blocking the activity of APPL1 antibody (MBS3223476)
Molecular Weight
77 kDa
OMIM
604299
3D Structure
ModBase 3D Structure for Q9UKG1
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human APPL1

Product Categories/Family for anti-APPL1 antibody

Polyclonal; Signaling Intermediate; Developmental Biology; DNA/RNA/Protein Interactions; Meiosis/Mitosis/Cell Cycle
Applications Tested/Suitable for anti-APPL1 antibody
Western Blot (WB)

Western Blot (WB) of anti-APPL1 antibody

Host: Rabbit
Target Name: APPL1
Sample Tissue: Human 786-0 Whole Cell lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-APPL1 Polyclonal Antibody – Cat# MBS3223476

Other Notes

Small volumes of anti-APPL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APPL1 purchase

MBS3223476 is an antibody targeting APPL1. Also known as APPL1 Antibody - C-terminal region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for APPL1. It may not necessarily be applicable to this product.

NCBI GI #
6912242
NCBI GeneID
26060
NCBI Accession #
NP_036228.1
UniProt Primary Accession #
Q9UKG1
UniProt Related Accession #
Q9UKG1
GenBank Nucleotide #
NM_012096.2
NCBI Official Full Name
DCC-interacting protein 13-alpha
NCBI Official Synonym Full Names
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
NCBI Official Symbol
APPL1
NCBI Official Synonym Symbols
APPL; MODY14; DIP13alpha
UniProt Protein Name
DCC-interacting protein 13-alpha
UniProt Synonym Protein Names
Adapter protein containing PH domain, PTB domain and leucine zipper motif 1
Protein Family
DCC-interacting protein
UniProt Gene Name
APPL1
UniProt Synonym Gene Names
APPL; DIP13A; KIAA1428; Dip13-alpha
UniProt Entry Name
DP13A_HUMAN
NCBI Protein Information
DCC-interacting protein 13-alpha

UniProt Comments for APPL1

APPL: an effector protein of the small GTPase Rab5, a key regulator of endocytosis. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Contains a PH domain and an N-terminal PID domain. Its interaction with RAB5A/Rab5 is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Phosphorylated upon DNA damage.

Protein type: Adaptor/scaffold; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: early endosome membrane; cytoplasm; endosome membrane; vesicle membrane; NuRD complex; nucleus; cytosol

Molecular Function: protein kinase B binding; identical protein binding; protein binding

Biological Process: cell proliferation; positive regulation of apoptosis; insulin receptor signaling pathway; regulation of glucose import; cell cycle; signal transduction

Disease: Maturity-onset Diabetes Of The Young, Type 14
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Research Articles on APPL1

1. Present study demonstrated that expression of APPL1 protein and mRNA was upregulated in gastric carcinoma (GC) tissues and cell lines. The expression of APPL1 in GC was statistically associated with metastasis stage. Overexpression of APPL1 promotes invasion and metastasis of gastric cancer cells and the underlying molecular mechanism may facilitate EMT via Akt2 phosphorylation.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-APPL1 antibody

 Reference Product  PubMed Publications
 ADIPOR1 antibody  >24 publications with APPL1 and ADIPOR1
 APPL2 antibody  >16 publications with APPL1 and APPL2
 AKT2 antibody  >5 publications with APPL1 and AKT2
 FSHR antibody  >4 publications with APPL1 and FSHR
 AKT1 antibody  >3 publications with APPL1 and AKT1
 RAB5A antibody  >2 publications with APPL1 and RAB5A
 TRAF2 antibody  >1 publications with APPL1 and TRAF2
 DCC antibody  >1 publications with APPL1 and DCC

Pathways associated with anti-APPL1 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Regulation Of Apoptosis Pathway antibodies  Regulation Of Apoptosis Pathway Diagram
 Role Of DCC In Regulating Apoptosis Pathway antibodies  Role Of DCC In Regulating Apoptosis Pathway Diagram

Diseases associated with anti-APPL1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with APPL1 and Inflammation
 Vascular Diseases Antibodies  >6 publications with APPL1 and Vascular Diseases
 Nervous System Diseases Antibodies  >6 publications with APPL1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >6 publications with APPL1 and Cardiovascular Diseases
 Abnormalities, Multiple Antibodies  >4 publications with APPL1 and Abnormalities, Multiple
 Kidney Diseases Antibodies  >4 publications with APPL1 and Kidney Diseases
 Necrosis Antibodies  >3 publications with APPL1 and Necrosis
 Cardiomyopathies Antibodies  >1 publications with APPL1 and Cardiomyopathies
 Abnormalities, Drug-Induced Antibodies  >1 publications with APPL1 and Abnormalities, Drug-Induced
 Bone Diseases Antibodies  >1 publications with APPL1 and Bone Diseases

Organs/Tissues associated with anti-APPL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >25 publications with APPL1 and Muscle
 Vascular Antibodies  >8 publications with APPL1 and Vascular
 Blood Antibodies  >8 publications with APPL1 and Blood
 Brain Antibodies  >7 publications with APPL1 and Brain
 Heart Antibodies  >6 publications with APPL1 and Heart
 Kidney Antibodies  >6 publications with APPL1 and Kidney
 Liver Antibodies  >6 publications with APPL1 and Liver
 Embryonic Tissue Antibodies  >5 publications with APPL1 and Embryonic Tissue
 Adipose Tissue Antibodies  >5 publications with APPL1 and Adipose Tissue
 Pancreas Antibodies  >3 publications with APPL1 and Pancreas
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