XBP1 Antibody – Rabbit Polyclonal

XBP1: a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 mRNA is spliced by IRE1 during the UPR to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. Only the spliced form of XBP1 can activate the UPR efficiently. Activates UPR target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I. Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum stress. Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7). Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. Two human isoforms are produced by alternative splicing. Isoform 1 is also known as XBP-1U. Isoform 2, also known as XBP-1S, is produced by IRE1 in response to endoplasmic reticulum stress. IRE1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 11 A1|11 3.61 cM

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; integral component of endoplasmic reticulum membrane; integral component of membrane; membrane; nucleus

Molecular Function: chromatin DNA binding; DNA binding; DNA binding transcription factor activity; histone deacetylase binding; identical protein binding; protease binding; protein heterodimerization activity; protein kinase binding; sequence-specific DNA binding; ubiquitin protein ligase binding

Biological Process: angiogenesis; apoptosis; autophagy; cell differentiation; cell growth; cellular response to glucose starvation; cellular response to insulin stimulus; cellular response to nutrient; cholesterol homeostasis; endoplasmic reticulum unfolded protein response; endothelial cell proliferation; epithelial cell maturation; exocrine pancreas development; fatty acid homeostasis; glucose homeostasis; lipid metabolic process; liver development; multicellular organism development; muscle organ development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; neuron development; phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; positive regulation of autophagy; positive regulation of B cell differentiation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of histone methylation; positive regulation of immunoglobulin production; positive regulation of immunoglobulin secretion; positive regulation of MHC class II biosynthetic process; positive regulation of protein phosphorylation; positive regulation of T cell differentiation; positive regulation of TOR signaling pathway; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription of target genes involved in unfolded protein response; protein destabilization; protein transport; regulation of autophagy; regulation of protein stability; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; response to drug; response to electrical stimulus; response to unfolded protein; serotonin secretion, neurotransmission; sterol homeostasis; transcription from RNA polymerase II promoter; transcription, DNA-dependent; transport; ubiquitin-dependent protein catabolic process; vascular endothelial growth factor receptor signaling pathway