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SSRP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3224600

This is a rabbit polyclonal antibody against SSRP1. It was validated on Western Blot using a cell lysate as a positive control.Target Description: SSRP1 is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
SSRP1, Polyclonal Antibody
Full Product Name
SSRP1 antibody - middle region
Product Gene Name
anti-SSRP1 antibody
Product Synonym Gene Name
FACT; FACT80; T160
Immunogen Sequence
Synthetic peptide located within the following region: MKEYEGGRGE SSKRDKSKKK KKVKVKMEKK STPSRGSSSK SSSRQLSESF
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Human, Mouse, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
SSRP1 peptide (MBS3225305) is used for blocking the activity of SSRP1 antibody (MBS3224600)
Molecular Weight
81kDa
OMIM
604328
3D Structure
ModBase 3D Structure for Q08945
Homology
Cow: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human SSRP1

Product Categories/Family for anti-SSRP1 antibody

Polyclonal; Transcription Factor; Transcription Regulation; Chromatin & Nuclear Signaling; Various; Epigenetics; DNA Damage & Repair; DNA Repair; Transcription Factors
Applications Tested/Suitable for anti-SSRP1 antibody
Western Blot (WB)

Western Blot (WB) of anti-SSRP1 antibody

WB Suggested Anti-SSRP1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Spleen
Rabbit Anti-SSRP1 Polyclonal Antibody – Cat# MBS3224600

Other Notes

Small volumes of anti-SSRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SSRP1 purchase

MBS3224600 is an antibody targeting SSRP1. Also known as SSRP1 antibody - middle region. Reactive in Cow, Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SSRP1. It may not necessarily be applicable to this product.

NCBI GI #
4507241
NCBI GeneID
6749
NCBI Accession #
NP_003137
UniProt Primary Accession #
Q08945
UniProt Related Accession #
Q08945
GenBank Nucleotide #
NM_003146
NCBI Official Full Name
FACT complex subunit SSRP1
NCBI Official Synonym Full Names
structure specific recognition protein 1
NCBI Official Symbol
SSRP1
NCBI Official Synonym Symbols
FACT; T160; FACT80
UniProt Protein Name
FACT complex subunit SSRP1
UniProt Synonym Protein Names
Chromatin-specific transcription elongation factor 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; FACT 80 kDa subunit; FACTp80; Facilitates chromatin transcription complex subunit SSRP1; Recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; hSSRP1; T160
Protein Family
FACT complex
UniProt Gene Name
SSRP1
UniProt Synonym Gene Names
FACT80; FACT 80 kDa subunit; FACTp80; hSSRP1
UniProt Entry Name
SSRP1_HUMAN
NCBI Protein Information
FACT complex subunit SSRP1

NCBI Summary for SSRP1

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]
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UniProt Comments for SSRP1

SSRP1: a subunit of the chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.

Protein type: Transcription initiation complex; Transcription, coactivator/corepressor; RNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: nucleoplasm; cytoplasm; nucleolus; chromosome; nucleus

Molecular Function: protein binding; DNA binding; chromatin binding

Biological Process: transcription from RNA polymerase II promoter; chromatin remodeling; regulation of transcription, DNA-dependent; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression; DNA repair; DNA replication
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Research Articles on SSRP1

1. regulation of SSRP1 by homodimerization

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SSRP1 antibody

 Reference Product  PubMed Publications
 SUPT16H antibody  >19 publications with SSRP1 and SUPT16H
 SRF antibody  >2 publications with SSRP1 and SRF
 CHD1 antibody  >2 publications with SSRP1 and CHD1
 SUPT4H1 antibody  >1 publications with SSRP1 and SUPT4H1
 MCM4 antibody  >1 publications with SSRP1 and MCM4
 MCM2 antibody  >1 publications with SSRP1 and MCM2

Pathways associated with anti-SSRP1 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Formation Of HIV Elongation Complex In The Absence Of HIV Tat Pathway antibodies  Formation Of HIV Elongation Complex In The Absence Of HIV Tat Pathway Diagram
 Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway antibodies  Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway Diagram
 Formation Of RNA Pol II Elongation Complex Pathway antibodies  Formation Of RNA Pol II Elongation Complex Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 HIV Transcription Elongation Pathway antibodies  HIV Transcription Elongation Pathway Diagram
 HIV Elongation Arrest And Recovery Pathway antibodies  HIV Elongation Arrest And Recovery Pathway Diagram
 Late Phase Of HIV Life Cycle Pathway antibodies  Late Phase Of HIV Life Cycle Pathway Diagram

Diseases associated with anti-SSRP1 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >5 publications with SSRP1 and Death
 Cell Transformation, Neoplastic Antibodies  >3 publications with SSRP1 and Cell Transformation, Neoplastic
 Skin Diseases Antibodies  >2 publications with SSRP1 and Skin Diseases
 Immune System Diseases Antibodies  >2 publications with SSRP1 and Immune System Diseases
 Disease Models, Animal Antibodies  >2 publications with SSRP1 and Disease Models, Animal
 Necrosis Antibodies  >2 publications with SSRP1 and Necrosis
 Nervous System Diseases Antibodies  >1 publications with SSRP1 and Nervous System Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with SSRP1 and Urinary Bladder Neoplasms
 Liver Neoplasms Antibodies  >1 publications with SSRP1 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with SSRP1 and Neoplasms, Experimental

Organs/Tissues associated with anti-SSRP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with SSRP1 and Blood
 Muscle Antibodies  >5 publications with SSRP1 and Muscle
 Lung Antibodies  >3 publications with SSRP1 and Lung
 Kidney Antibodies  >2 publications with SSRP1 and Kidney
 Vascular Antibodies  >1 publications with SSRP1 and Vascular
 Liver Antibodies  >1 publications with SSRP1 and Liver
 Bladder Antibodies  >1 publications with SSRP1 and Bladder
 Brain Antibodies  >1 publications with SSRP1 and Brain
 Embryonic Tissue Antibodies  >1 publications with SSRP1 and Embryonic Tissue
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