• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

IRF8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3224625

This is a rabbit polyclonal antibody against IRF8. It was validated on Western Blot and immunohistochemistryTarget Description: Interferon regulatory factor 8 (IRF8, interferon consensus sequence-binding protein, Ion ChannelSBP) is a transcription factor of… More details

$490 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IRF8, Polyclonal Antibody
Full Product Name
IRF8 antibody - N-terminal region
Product Gene Name
Product Synonym Gene Name
ICSBP; IRF-8; ICSBP1; H-ICSBP
Immunogen Sequence
Synthetic peptide located within the following region: MFRIPWKHAG KQDYNQEVDA SIFKAWAVFK GKFKEGDKAE PATWKTRLRC
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
IRF8 peptide (MBS3225347) is used for blocking the activity of IRF8 antibody (MBS3224625)
Molecular Weight
48kDa
3D Structure
ModBase 3D Structure for Q02556
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human IRF8
Applications Tested/Suitable for anti-IRF8 antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-IRF8 antibody

Immunohistochemistry with Human Intestine tissue
Rabbit Anti-IRF8 Polyclonal Antibody – Cat# MBS3224625

Immunohistochemistry (IHC) of anti-IRF8 antibody

Immunohistochemistry with Human Liver cell lysate tissue
Rabbit Anti-IRF8 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3224625

Western Blot (WB) of anti-IRF8 antibody

Host: Rabbit
Target Name: IRF8
Sample Tissue: Human DLD1 Whole Cell
Antibody Dilution: 1ug/ml
Rabbit Anti-IRF8 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3224625

Western Blot (WB) of anti-IRF8 antibody

Host: Rabbit
Target Name: IRF8
Sample Tissue: Human Ovary Tumor
Antibody Dilution: 1.0ug/ml
Rabbit Anti-IRF8 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3224625

Western Blot (WB) of anti-IRF8 antibody

WB Suggested Anti-IRF8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate
Rabbit Anti-IRF8 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3224625

Other Notes

Small volumes of anti-IRF8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IRF8 purchase

MBS3224625 is an antibody targeting IRF8. Also known as IRF8 antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IRF8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interferon regulatory factor 8 isoform 2
NCBI Official Synonym Full Names
interferon regulatory factor 8
NCBI Official Symbol
IRF8
NCBI Official Synonym Symbols
ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP
UniProt Protein Name
Interferon regulatory factor 8
UniProt Synonym Protein Names
Interferon consensus sequence-binding protein; H-ICSBP; ICSBP
UniProt Gene Name
IRF8
UniProt Synonym Gene Names
ICSBP1; IRF-8; H-ICSBP; ICSBP
NCBI Protein Information
interferon regulatory factor 8

NCBI Summary for IRF8

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for IRF8

Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes ().
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IRF8 antibody

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000