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ERN2 Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS003257

MBS003257 is an antibody targeting ERN2. Also known as Rabbit ERN2 Antibody. Reactive in Human, mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ERN2, Antibody
Full Product Name
Rabbit ERN2 Antibody
Product Gene Name
anti-ERN2 antibody
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Molecular Weight
102,480 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (23701625..23724821, complement). Location: 16p12.2
OMIM
604034
3D Structure
ModBase 3D Structure for Q76MJ5
Applications Tested/Suitable for anti-ERN2 antibody
Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA (EIA)

Other Notes

Small volumes of anti-ERN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ERN2. It may not necessarily be applicable to this product.

NCBI GI #
145312265
NCBI GeneID
10595
NCBI Accession #
NP_150296.3
UniProt Primary Accession #
Q76MJ5
UniProt Secondary Accession #
Q6ZNC0
UniProt Related Accession #
Q76MJ5
GenBank Nucleotide #
NM_033266.3
NCBI Official Full Name
serine/threonine-protein kinase/endoribonuclease IRE2
NCBI Official Synonym Full Names
endoplasmic reticulum to nucleus signaling 2
NCBI Official Symbol
ERN2
NCBI Official Synonym Symbols
IRE1b; IRE1-BETA
UniProt Protein Name
Serine/threonine-protein kinase/endoribonuclease IRE2
UniProt Synonym Protein Names
Endoplasmic reticulum-to-nucleus signaling 2; Inositol-requiring protein 2; hIRE2p; Ire1-beta
Protein Family
Serine/threonine-protein kinase/endoribonuclease
UniProt Gene Name
ERN2
UniProt Synonym Gene Names
IRE2; hIRE2p; IRE1b
UniProt Entry Name
ERN2_HUMAN
NCBI Protein Information
serine/threonine-protein kinase/endoribonuclease IRE2; hIRE2p; IRE1 beta; inositol-requiring 1 beta; ER to nucleus signalling 2; inositol-requiring protein 2; IRE1, S. cerevisiae, homolog of; endoplasmic reticulum-to-nucleus signaling 2; endoplasmic reticulum to nucleus signalling 2

UniProt Comments for ERN2

IRE2: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Membrane protein, integral; EC 2.7.11.1; Apoptosis; Ribonuclease; Protein kinase, Other; Other group; IRE family

Chromosomal Location of Human Ortholog: 16p12.2

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: protein serine/threonine kinase activity; endonuclease activity; magnesium ion binding; ATP binding; ribonuclease activity

Biological Process: transcription, DNA-dependent; rRNA catabolic process; apoptotic chromosome condensation; mRNA processing; cell cycle arrest; negative regulation of transcription, DNA-dependent; protein amino acid phosphorylation
Show more

Research Articles on ERN2

1. The luminal event mediated by IRE1beta involves direct interaction with unfolded proteins rather than association/dissociation with BiP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-ERN2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >23 publications with ERN2 and Neoplasms
 Inflammation Antibodies  >12 publications with ERN2 and Inflammation
 Vascular Diseases Antibodies  >10 publications with ERN2 and Vascular Diseases
 Necrosis Antibodies  >10 publications with ERN2 and Necrosis
 Insulin Resistance Antibodies  >6 publications with ERN2 and Insulin Resistance
 Atherosclerosis Antibodies  >5 publications with ERN2 and Atherosclerosis
 Carcinoma Antibodies  >4 publications with ERN2 and Carcinoma
 Liver Diseases Antibodies  >4 publications with ERN2 and Liver Diseases
 Immune System Diseases Antibodies  >4 publications with ERN2 and Immune System Diseases
 Lung Diseases Antibodies  >3 publications with ERN2 and Lung Diseases

Organs/Tissues associated with anti-ERN2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with ERN2 and Brain
 Pancreas Antibodies  >13 publications with ERN2 and Pancreas
 Kidney Antibodies  >7 publications with ERN2 and Kidney
 Intestine Antibodies  >6 publications with ERN2 and Intestine
 Lung Antibodies  >4 publications with ERN2 and Lung
 Mouth Antibodies  >2 publications with ERN2 and Mouth
 Prostate Antibodies  >1 publications with ERN2 and Prostate
 Bladder Antibodies  >1 publications with ERN2 and Bladder
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