Adrenocorticotropic Hormone Receptor (ACTHR) ELISA Kit for Rat

Name: Rat ACTHR ELISA Kit; Adrenocorticotropic Hormone Receptor; MyBioSource
Brand: MyBioSource
SKU: MBS033215
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS033215

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only! This kit is intended to be used to determine the level of ACTH (hereafter termed "analyte") in undiluted original Rat serum, plasma or tissue homogenates… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Adrenocorticotropic Hormone Receptor (ACTHR), ELISA Kit

Full Product Name

Rat Adrenocorticotropic Hormone Receptor ELISA Kit

Product Gene Name

ACTHR elisa kit

Species Reactivity

Rat

Assay Type

Quantitative Sandwich

Samples

Cat Serum, Plasma Or Tissue Homogenates Samples

Detection Range

6.25pg/ml-200pg/ml

Sensitivity

1.0pg/ml.

Preparation and Storage

Store all reagents at 2-8 degree C

Inter-assay Precision

Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Intra-assay Precision

Intra-assay CV (%) is less than 15%

Molecular Weight

33,927 Da

Chromosome Location

Chromosome: 18; NC_000018.9 (13882043..13915535, complement). Location: 18p11.2

OMIM

202200

3D Structure

ModBase 3D Structure for Q01718

Reactivity Note

Cat reactivity is predicted based on homology with the human ACTH sequence and also positive reference data for cat samples with this assay. Please inquire for additional information

Other Notes

Small volumes of ACTHR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACTHR purchase

MBS033215 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Adrenocorticotropic Hormone Receptor (ACTHR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACTHR. The ELISA analytical biochemical technique of the MBS033215 kit is based on ACTHR antibody-ACTHR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACTHR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACTHR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for ACTHR. It may not necessarily be applicable to this product.

NCBI GI #

4505127

NCBI GeneID

4158

NCBI Accession #

NP_000520.1

UniProt Primary Accession #

Q01718

UniProt Secondary Accession #

Q3MI45; Q504X6; A8K016

UniProt Related Accession #

Q01718

GenBank Nucleotide #

NM_000529.2

NCBI Official Full Name

adrenocorticotropic hormone receptor

NCBI Official Synonym Full Names

melanocortin 2 receptor (adrenocorticotropic hormone)

NCBI Official Symbol

MC2R

NCBI Official Synonym Symbols

ACTHR

UniProt Protein Name

Adrenocorticotropic hormone receptor

UniProt Synonym Protein Names

Adrenocorticotropin receptor; Melanocortin receptor 2

Protein Family

Adrenocorticotropic hormone receptor

UniProt Gene Name

MC2R

UniProt Synonym Gene Names

ACTHR; ACTH receptor; ACTH-R; MC2-R

UniProt Entry Name

ACTHR_HUMAN

NCBI Protein Information

adrenocorticotropic hormone receptor; MC2 receptor; ACTH receptor; corticotropin receptor; adrenocorticotropin receptor

NCBI Summary for ACTHR

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. [provided by RefSeq, Jul 2008]

UniProt Comments for ACTHR

MC2R: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1); also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 18p11.2

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; melanocortin receptor activity; adrenocorticotropin receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; placenta development

Disease: Glucocorticoid Deficiency 1

Research Articles on ACTHR

1. Significant differences in the gene expression of aldosterone synthase and adrenocorticotropic hormone receptor distinguishes adrenal neoplasms from primary aldosteronism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ACTHR elisa kit

Reference Product	PubMed Publications
POMC elisa kit	>110 publications with ACTHR and POMC
MRAP elisa kit	>53 publications with ACTHR and MRAP
MC1R elisa kit	>24 publications with ACTHR and MC1R
CRH elisa kit	>13 publications with ACTHR and CRH
FSHR elisa kit	>2 publications with ACTHR and FSHR
CRHR2 elisa kit	>2 publications with ACTHR and CRHR2
ADCYAP1 elisa kit	>1 publications with ACTHR and ADCYAP1
GIPR elisa kit	>1 publications with ACTHR and GIPR

Pathways associated with ACTHR elisa kit

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Peptide GPCRs Pathway antibodies	Peptide GPCRs Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with ACTHR elisa kit

Disease Name	Pubmed Publications
GLUCOCORTICOID DEFICIENCY 1 Antibodies	>33 publications with ACTHR and GLUCOCORTICOID DEFICIENCY 1
Nervous System Diseases Antibodies	>10 publications with ACTHR and Nervous System Diseases
Hyperplasia Antibodies	>7 publications with ACTHR and Hyperplasia
Seizures Antibodies	>7 publications with ACTHR and Seizures
Inflammation Antibodies	>5 publications with ACTHR and Inflammation
Drug Toxicity Antibodies	>4 publications with ACTHR and Drug Toxicity
Hypertension Antibodies	>4 publications with ACTHR and Hypertension
Adenocarcinoma Antibodies	>3 publications with ACTHR and Adenocarcinoma
Urogenital Abnormalities Antibodies	>2 publications with ACTHR and Urogenital Abnormalities
Disease Models, Animal Antibodies	>2 publications with ACTHR and Disease Models, Animal

Organs/Tissues associated with ACTHR elisa kit

Organ/Tissue Name	Pubmed Publications
Adrenal Gland Antibodies	>64 publications with ACTHR and Adrenal Gland
Brain Antibodies	>36 publications with ACTHR and Brain