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IP-10 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS335101

MBS335101 is an antibody targeting IP-10. Also known as Mouse Anti-Human IP-10 Monoclonal Antibody, FITC Conjugated Clone B-C50. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IP-10, Monoclonal Antibody
Full Product Name
Mouse Anti-Human IP-10 Monoclonal Antibody, FITC Conjugated Clone B-C50
Product Gene Name
anti-IP-10 antibody
Product Synonym Names
IP-10
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
B-C50
Host
Mouse
Species Reactivity
Human
Form/Format
Phosphate-buffered saline with 5 % BSA and 0.1 % sodium azide
Purity/Purification
Ion exchange chromatography (and affinity chromatography for certain batches)
Specificity
Recognises both natural and recombinant human IP-10
Preparation and Storage
Store at +2-8 degree C for 12 months. For longer storage, freeze aliquots.
Matching Pairs
FITC Conjugated Antibody: IP-10 Clone #B-C50 (MBS335101)
Unconjugated Antibody: IP-10 Clone #B-C50 (MBS335193)
Matching Pairs
Unconjugated Azide Free Antibody: IP-10 Clone #B-C50 (MBS335157)
FITC Conjugated Antibody: IP-10 Clone #B-C50 (MBS335101)
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Molecular Weight
10,789 Da
3D Structure
ModBase 3D Structure for P17515
Antigen
IP-10
Hybridoma
Myeloma X63/AG.8653 x Balb/c lymph node cells
Immunisation
Recombinant human IP-10
Conjugation
FITC
Applications Tested/Suitable for anti-IP-10 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-IP-10 antibody
Working Dilution: Use 10 mul to label 106 cells or 100 mul of whole blood

Testing Data of anti-IP-10 antibody

We used U937 cells 3 days after passaging. Half were activated with IFN-gamma 100 ng/ml for 20 hours and half were used as control. Cell concentration at the beginning of activation was 2.105 cells/ml. Brefaldin A was used as an intracellular blocking agent at 1ug/ml, in contact with the cells for 4 to 6 hours. The black line on the graph represents the IgG2b isotype control (B-E4), the green line shows B-C50 with U937 non-activated cells and the yellow line represents activated U937 cells marked with B-C50 (10ul per test for 5.105 cells)
Mouse Anti-IP-10 Monoclonal Antibody – Cat# MBS335101

Other Notes

Small volumes of anti-IP-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IP-10. It may not necessarily be applicable to this product.

NCBI GI #
976159
NCBI GeneID
15945
NCBI Accession #
AAA75249.1
UniProt Primary Accession #
P17515
UniProt Related Accession #
P17515
NCBI Official Full Name
IP-10
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 10
NCBI Official Symbol
Cxcl10
NCBI Official Synonym Symbols
C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10
UniProt Protein Name
C-X-C motif chemokine 10
UniProt Synonym Protein Names
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10
UniProt Gene Name
Cxcl10
UniProt Synonym Gene Names
Crg2; Ifi10; Inp10; Scyb10; Gamma-IP10; IP-10
UniProt Entry Name
CXL10_MOUSE
NCBI Protein Information
C-X-C motif chemokine 10

UniProt Comments for IP-10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Chemokine; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space; cell; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; negative regulation of myoblast differentiation; defense response to virus; positive regulation of cell migration
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Research Articles on IP-10

1. The chemokines monocyte chemotactic protein 1 (MCP1), MIP1alpha, MIP1beta, interferon gamma-induced protein 10 (IP-10), and eotaxin were induced in Saa1 TG mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IP-10 antibody

 Reference Product  PubMed Publications
 Cxcl9 antibody  >964 publications with IP-10 and Cxcl9
 Cxcr3 antibody  >860 publications with IP-10 and Cxcr3
 Ccl5 antibody  >669 publications with IP-10 and Ccl5
 Ccr5 antibody  >178 publications with IP-10 and Ccr5
 Cxcl2 antibody  >116 publications with IP-10 and Cxcl2
 Ccl20 antibody  >110 publications with IP-10 and Ccl20
 Cxcl5 antibody  >66 publications with IP-10 and Cxcl5
 Cxcl13 antibody  >52 publications with IP-10 and Cxcl13
 Cxcr5 antibody  >28 publications with IP-10 and Cxcr5

Pathways associated with anti-IP-10 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with anti-IP-10 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1232 publications with IP-10 and Inflammation
 Necrosis Antibodies  >692 publications with IP-10 and Necrosis
 Disease Models, Animal Antibodies  >359 publications with IP-10 and Disease Models, Animal
 Lung Diseases Antibodies  >350 publications with IP-10 and Lung Diseases
 Liver Diseases Antibodies  >248 publications with IP-10 and Liver Diseases
 Brain Diseases Antibodies  >214 publications with IP-10 and Brain Diseases
 Cardiovascular Diseases Antibodies  >181 publications with IP-10 and Cardiovascular Diseases
 Fibrosis Antibodies  >132 publications with IP-10 and Fibrosis
 Neoplasms, Experimental Antibodies  >123 publications with IP-10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >92 publications with IP-10 and Kidney Diseases

Organs/Tissues associated with anti-IP-10 antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >164 publications with IP-10 and Lymph Node
 Spleen Antibodies  >137 publications with IP-10 and Spleen
 Bone Marrow Antibodies  >134 publications with IP-10 and Bone Marrow
 Eye Antibodies  >99 publications with IP-10 and Eye
 Intestine Antibodies  >98 publications with IP-10 and Intestine
 Embryonic Tissue Antibodies  >54 publications with IP-10 and Embryonic Tissue
 Thymus Antibodies  >53 publications with IP-10 and Thymus
 Mammary Gland Antibodies  >8 publications with IP-10 and Mammary Gland
 Epididymis Antibodies  >1 publications with IP-10 and Epididymis
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