Mouse Anti-MICB Monoclonal Antibody – Cat# MBS8103813

Analysis of anti-MICB on HeLa cells.

MICB Antibody – Mouse Monoclonal

Name: MICB Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS8103813
Price: 190 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8103813

MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related protein, both of which contain three… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MICB, Monoclonal Antibody

Full Product Name

Anti-MICB Antibody (PE), Mouse Monoclonal

Product Gene Name

anti-MICB antibody

Product Synonym Names

MICB/MIC-B Antibody (PE), Mouse MAb; MHC class I polypeptide-related sequence B; Anti-PERB11.2 Antibody

Clonality

Monoclonal

Isotype

Mouse IgG1

Clone Number

Host

Mouse

Species Reactivity

Human

Form/Format

Liquid; Aqueous solution containing 0.5% BSA and 0.1% sodium azide

Purity/Purification

Protein A

Concentration

10ul/Test, 0.1mg/ml (lot specific)

Specificity

Human MICB/MIC-B

Preparation and Storage

This antibody can be stored at 2-8 degree C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Molecular Weight

42,646 Da

Chromosome Location

Chromosome: 6; NC_000006.12 (31494881..31511124). Location: 6p21.3

OMIM

180300

3D Structure

ModBase 3D Structure for Q29980

Immunogen

Recombinant Human MICB/MIC-B protein

Conjugation

Preparation

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MICB/MIC-B (rh MICB/MIC-B) and conjugated with PE under optimum conditions, the unreacted PE was removed.

Applications Tested/Suitable for anti-MICB antibody

Flow Cytometry (FC/FACS/FCM)

Product References and Citations for anti-MICB antibody

Bauer, S. et al., 1999, Science. 285:727-729. Braud, V.M. et al., 1999, Curr. Opin. Immunol. 11: 100-108. Groh, V. et al., 2001, Nature Immunol. 2: 255-260. Stephens, H., 2001, Trends Immunol. 22: 378-385. Borrego, F. et al., 2002, Mol. Immunol. 38: 637-660. Groh, V. et al., 2002, Nature. 419:734-738.

Other Notes

Small volumes of anti-MICB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MICB purchase

MBS8103813 is an antibody targeting MICB. Also known as Anti-MICB Antibody (PE), Mouse Monoclonal. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MICB. It may not necessarily be applicable to this product.

NCBI GI #

167857788

NCBI GeneID

4277

NCBI Accession #

NP_005922.2

UniProt Primary Accession #

Q29980

UniProt Secondary Accession #

O14499; O14500; O19798; O19799; O19800; O19801; O19802; O19803; O78099; A6NP85; B0UZ10

UniProt Related Accession #

Q29980

GenBank Nucleotide #

NM_005931.4

NCBI Official Full Name

MHC class I polypeptide-related sequence B isoform 1

NCBI Official Synonym Full Names

MHC class I polypeptide-related sequence B

NCBI Official Symbol

MICB

NCBI Official Synonym Symbols

PERB11.2

UniProt Protein Name

MHC class I polypeptide-related sequence B

Protein Family

MHC class I polypeptide-related sequence

UniProt Gene Name

MICB

UniProt Synonym Gene Names

MIC-B

UniProt Entry Name

MICB_HUMAN

NCBI Protein Information

MHC class I polypeptide-related sequence B; MHC class I mic-B antigen; stress inducible class I homolog; MHC class I chain-related protein B; MHC class I-like molecule PERB11.2-IMX

NCBI Summary for MICB

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

UniProt Comments for MICB

MICB: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. The MICB*004 allele is associated with rheumatoid arthritis. Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk. Belongs to the MHC class I family. MIC subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cell surface; integral to membrane; plasma membrane

Molecular Function: beta-2-microglobulin binding; antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; regulation of immune response; response to retinoic acid; viral reproduction; response to heat; natural killer cell mediated cytotoxicity; cytolysis; immune response-activating cell surface receptor signaling pathway; negative regulation of defense response to virus by host; response to oxidative stress; gamma-delta T cell activation; T cell mediated cytotoxicity

Research Articles on MICB

1. Diverse MICB alleles differentially bound cytomegalovirus UL16.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MICB antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Natural Killer Cell Mediated Cytotoxicity Pathway antibodies	Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
Natural Killer Cell Mediated Cytotoxicity Pathway antibodies	Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Diseases associated with anti-MICB antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>124 publications with MICB and Neoplasms
Carcinoma Antibodies	>43 publications with MICB and Carcinoma
Adenocarcinoma Antibodies	>21 publications with MICB and Adenocarcinoma
Necrosis Antibodies	>16 publications with MICB and Necrosis
Liver Diseases Antibodies	>15 publications with MICB and Liver Diseases
Liver Neoplasms Antibodies	>10 publications with MICB and Liver Neoplasms
Neoplasms, Experimental Antibodies	>9 publications with MICB and Neoplasms, Experimental
Carcinoma, Hepatocellular Antibodies	>9 publications with MICB and Carcinoma, Hepatocellular
Pancreatic Neoplasms Antibodies	>9 publications with MICB and Pancreatic Neoplasms
Colorectal Neoplasms Antibodies	>8 publications with MICB and Colorectal Neoplasms

Organs/Tissues associated with anti-MICB antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>196 publications with MICB and Blood
Liver Antibodies	>15 publications with MICB and Liver
Lung Antibodies	>14 publications with MICB and Lung
Kidney Antibodies	>10 publications with MICB and Kidney
Intestine Antibodies	>9 publications with MICB and Intestine
Bone Marrow Antibodies	>7 publications with MICB and Bone Marrow
Lymph Antibodies	>6 publications with MICB and Lymph
Brain Antibodies	>5 publications with MICB and Brain
Vascular Antibodies	>3 publications with MICB and Vascular
Embryonic Tissue Antibodies	>3 publications with MICB and Embryonic Tissue