Mouse Anti-IL-34 Monoclonal Antibody – Cat# MBS335764

IL-34 Antibody – Mouse Monoclonal

Name: IL-34 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS335764
Price: 355 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS335764

MBS335764 is an antibody targeting IL-34. Also known as Anti-Human IL-34 Azide Free. Host: Mouse. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL-34, Monoclonal Antibody

Full Product Name

Anti-Human IL-34 Azide Free

Product Gene Name

anti-IL-34 antibody

Clonality

Monoclonal

Isotype

IgG1 Kappa light chain

Clone Number

B-R34

Host

Mouse

Form/Format

Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free. Azide free

Specificity

Recognizes both recombinant and natural human IL-34

Preparation and Storage

Stable at 2-8 degree C for 12 months

Matching Pairs

Biotin Conjugated Antibody: IL-34 Clone #B-R34 (MBS335836)
Unconjugated Azide Free Antibody: IL-34 Clone #B-R34 (MBS335764)

Molecular Weight

27,354 Da

OMIM

612081

Hybridoma

Myeloma X63/AG.8653 x Balb/c node cells

Immunisation

Recombinant human IL-34

Applications Tested/Suitable for anti-IL-34 antibody

ELISA (EIA)

Other Notes

Small volumes of anti-IL-34 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-34. It may not necessarily be applicable to this product.

NCBI GI #

289666752

NCBI GeneID

146433

NCBI Accession #

NP_001166243.1

UniProt Secondary Accession #

Q8N6L2; B2RC28; B2Z4A8; B2ZC70

UniProt Related Accession #

Q6ZMJ4

GenBank Nucleotide #

NM_001172772.1

NCBI Official Full Name

interleukin-34 isoform 1

NCBI Official Synonym Full Names

interleukin 34

NCBI Official Symbol

IL34

NCBI Official Synonym Symbols

IL-34; C16orf77

UniProt Protein Name

Interleukin-34

UniProt Gene Name

IL34

UniProt Synonym Gene Names

C16orf77; IL-34

UniProt Entry Name

IL34_HUMAN

NCBI Protein Information

interleukin-34

NCBI Summary for IL-34

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

UniProt Comments for IL-34

IL34: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Belongs to the IL-34 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; macrophage colony stimulating factor receptor binding

Biological Process: inflammatory response; innate immune response; positive regulation of cell proliferation; positive regulation of macrophage differentiation; positive regulation of monocyte differentiation; positive regulation of protein amino acid phosphorylation

Research Articles on IL-34

1. These results suggest that IL-34, a novel osteoclastogenic cytokine, plays a role in rheumatoid arthritis-associated joint damage and is a potential biomarker for predicting subsequent radiographic progression in patients with RA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IL-34 antibody

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Signaling By Interleukins Pathway antibodies	Signaling By Interleukins Pathway Diagram

Diseases associated with anti-IL-34 antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>3 publications with IL-34 and Necrosis
Inflammation Antibodies	>3 publications with IL-34 and Inflammation
Diabetes Mellitus Antibodies	>2 publications with IL-34 and Diabetes Mellitus

Organs/Tissues associated with anti-IL-34 antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>4 publications with IL-34 and Bone
Embryonic Tissue Antibodies	>3 publications with IL-34 and Embryonic Tissue
Skin Antibodies	>2 publications with IL-34 and Skin
Brain Antibodies	>2 publications with IL-34 and Brain
Intestine Antibodies	>1 publications with IL-34 and Intestine