Peroxisome Proliferators Activator Gammaelisa (PPAR-gamma) ELISA Kit for Goose

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

PPAR-gamma: a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytosol; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; transcription activator binding; zinc ion binding; drug binding; alpha-actinin binding; protein phosphatase binding; retinoid X receptor binding; arachidonic acid binding; protein binding; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; DNA binding; prostaglandin receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; estrogen receptor binding; chromatin binding; transcription factor activity

Biological Process: negative regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of collagen biosynthetic process; heart development; cell maturation; low-density lipoprotein receptor biosynthetic process; rhythmic process; lipid homeostasis; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to lipid; glucose homeostasis; response to vitamin A; response to caffeine; epithelial cell differentiation; regulation of blood pressure; positive regulation of oligodendrocyte differentiation; response to nutrient; placenta development; long-chain fatty acid transport; caspase activation; transcription initiation from RNA polymerase II promoter; organ regeneration; cell fate commitment; response to retinoic acid; monocyte differentiation; negative regulation of acute inflammatory response; regulation of circadian rhythm; response to starvation; G-protein coupled receptor protein signaling pathway; negative regulation of telomerase activity; cellular response to insulin stimulus; lipoprotein transport; response to estrogen stimulus; response to mechanical stimulus; response to low density lipoprotein stimulus; positive regulation of fatty acid oxidation; white fat cell differentiation; brown fat cell differentiation; positive regulation of fat cell differentiation; innate immune response; positive regulation of transcription factor activity; steroid hormone mediated signaling; fatty acid oxidation; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to cold; negative regulation of cell growth; lipid metabolic process; positive regulation of phagocytosis, engulfment; negative regulation of transcription, DNA-dependent

Disease: Obesity; Lipodystrophy, Familial Partial, Type 3; Carotid Intimal Medial Thickness 1; Diabetes Mellitus, Noninsulin-dependent