E-Selectin (SELE) Antibody – Sheep Polyclonal

The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

SELE: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Belongs to the selectin/LECAM family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22-q25

Cellular Component: caveola; coated pit; cortical cytoskeleton; extracellular space; lipid raft; perinuclear region of cytoplasm; plasma membrane

Molecular Function: phospholipase binding; protein binding; sialic acid binding; transmembrane receptor activity

Biological Process: actin filament-based process; calcium-mediated signaling; heterophilic cell adhesion; inflammatory response; leukocyte adhesion; leukocyte migration; leukocyte migration during inflammatory response; leukocyte tethering or rolling; phospholipase C activation; positive regulation of receptor internalization; regulation of inflammatory response; response to lipopolysaccharide

Disease: Hypertension, Essential