Interleukin 7 (IL-7) Antibody – Sheep Polyclonal

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Apoptosis; Cell cycle regulation; Secreted, signal peptide; Secreted; Cell development/differentiation

Chromosomal Location of Human Ortholog: 8q12-q13

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; protein binding

Biological Process: bone resorption; cell-cell signaling; humoral immune response; negative regulation of apoptosis; organ morphogenesis; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of T cell differentiation; T cell lineage commitment