Naltrexone Antibody – Sheep Polyclonal

Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. It is marketed in generic form as its hydrochloride salt, naltrexone hydrochloride, and marketed under the trade names Revia and Depade. Naltrexone and its active metabolite 6-beta-naltrexol are competitive antagonists at ¦- and beta-opioid receptors, and to a lesser extent at beta-opioid receptors.[1] The plasma half-life of naltrexone is about 4 h, for 6-beta-naltrexol 13 h. The blockade of opioid receptors is the basis behind its action in the management of opioid dependence - it reversibly blocks or attenuates the effects of opioids. Its use in alcohol (ethanol) dependence has been studied and has been shown to be effective. Naltrexone is metabolized mainly to 6beta-naltrexol by the liver enzyme dihydrodiol dehydrogenase. Other metabolites include 2-hydroxy-3-methoxy-6beta-naltrexol and 2-hydroxy-3-methoxy-naltrexone. These are then further metabolized by conjugation with glucuronide.

1. Shader, RI. Antagonists, Inverse Agonists, and Protagonists. Journal of Clinical Psychopharmacology. 2003 Aug; 23(4):321?322. PMID 12920406

Small volumes of anti-Naltrexone antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS340532 is an antibody targeting Naltrexone. Host: Sheep.