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Paraoxonase 2 (PO-2) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS343103

Paraoxonase 1 is involved in the detoxification of organophosphate insecticides such as parathion. Paraoxonase 1 may also confer protection against coronary artery disease by destroying proinflammatory oxidized lipids present in oxidized low-density… More details

$385 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Paraoxonase 2 (PO-2), Recombinant Protein
Full Product Name
Paraoxonase 2 (PO-2)
Product Gene Name
Product Synonym Names
Paraoxonase 2, PON 2, Serum paraoxonase/arylesterase 2, aryldialkylphosphatase 2, A-esterase 2, Aromatic esterase 2
Purity/Purification
>95%
Concentration
1.00 mg/ml (lot specific)
Preparation and Storage
Store at -20°C.
Vial should be centrifuged briefly before opening to ensure contents are not lost when removing cap.
Molecular Weight
43.5kDa
OMIM
602447
3D Structure
ModBase 3D Structure for Q15165
Total Volume
1.00ml
Total Protein
100ug
Buffer
20mM Tris HCl pH 8, 50% Glycerol.
ISO Certification
Manufactured in an ISO 13485:2016 Certified Laboratory.

Product References and Citations for PO-2 recombinant protein

Rosenblat M. et al. (2003) Arterioscler Thromb Vasc Biol. 23(3): 468-74.

Other Notes

Small volumes of PO-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PO-2 purchase

MBS343103 is a recombinant protein targeting PO-2. Also known as Paraoxonase 2 (PO-2).

Additional Details

NCBI/Uniprot data below describe general gene information for PO-2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
paraoxonase 2
NCBI Official Synonym Full Names
paraoxonase 2
NCBI Official Symbol
PON2
UniProt Protein Name
Serum paraoxonase/arylesterase 2
UniProt Synonym Protein Names
Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2
UniProt Gene Name
PON2
UniProt Synonym Gene Names
PON 2; A-esterase 2
UniProt Entry Name
PON2_HUMAN
NCBI Protein Information
serum paraoxonase/arylesterase 2

NCBI Summary for PO-2

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for PO-2

PON2: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. Belongs to the paraoxonase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.81; Motility/polarity/chemotaxis; EC 3.1.1.2; Hydrolase

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: plasma membrane

Molecular Function: identical protein binding

Biological Process: aromatic compound catabolic process; response to toxin
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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