ST-2 Recombinant Protein

The ST2 gene is a member of the IL-1 receptor family, encoding a transmembrane protein with a structure similar to IL-1R1. A soluble form of the protein (ST2) is produced from the same gene by alternative splicing and is reported to be expressed in several cell types including fibroblasts and mast cells. Soluble ST2 has been reported to act as a negative regulator of Th2 cytokine production and elevated levels have been reported in several disease states and conditions including asthma, sepsis and myocardial infarction. Recombinant ST2 comprises a 310 amino acid fragment (19-328) corresponding to the soluble ST2 coding sequence and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use

Trajkovic V et al., (2004) Cytokine Growth Factor Rev. 15(2-3): 87- 95.

Small volumes of ST-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS343176 is a recombinant protein targeting ST-2.