Pencillin Binding Protein 2x (PBP-2X) Recombinant Protein

Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Penicillin Binding Protein 2X is a membrane bound transpeptidase belong to the high molecular weight class B group of penicillin binding proteins. This enzyme is one of the primary targets of beta-lactam antibiotics in Streptococcus pneumoniae. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins. Recombinant Penicillin Binding Protein 2X comprises a 701 amino acid fragment (50-750) corresponding to the mature PBP-2X protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

Laible, G. et.al. 1992 Eur. J. Biochem. (207): 943-949.

Small volumes of PBP-2X recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS343280 is a recombinant protein targeting PBP-2X. Also known as Pencillin Binding Protein 2X (PBP-2X).