CDX-2 Antibody – Rabbit Monoclonal

Intended Use: This antibody is intended for in IVD use. The CDX-2 [IHC302] antibody is intended for qualified laboratories to qualitatively identify by light microscopy, the presence of associated antigens in formalin-fixed, paraffin-embedded (FFPE) tissue sections using immunohistochemistry test methods. Use of this antibody is indicated, subsequent to clinical differential test of diseases, as an aid in the identification of neoplastic tissues within the context of antibody panels, the patient’s clinical history and other tests as evaluated by a qualified pathologist.

Summary and Explanation: CDX-2 is a caudal-related homeobox transcription factor that is expressed by intestinal epithelial cells. CDX-2 is a useful marker for gastrointestinal carcinoma and for determining the origin of gastrointestinal metastatic adenocarcinoma and carcinoid tumours. Anti-CDX-2 is used for differentiating lung and metastatic colorectal adenocarcinoma. However, mucinous ovarian carcinoma also reacts positively with Anti-CDX-2, thereby limiting the ability to differentiate from metastatic colorectal adenocarcinoma.

Principles and Procedures Visualization of the antigen present in tissue sections is accomplished in a multi-step immunohistochemical staining process, in conjunction with a horseradish peroxidase (HRP) or alkaline phosphatase (AP) linked detection system. The process involves the addition of the stated antibody (primary antibody) to a tissue slide, followed by a secondary antibody (linked to an enzyme complex) which specifically binds to the primary antibody. A chromogenic substrate is then added which reacts with the enzyme complex, resulting in a colorimetric reaction at the site of the antigen. Results are interpreted using a light microscope.

Small volumes of anti-CDX-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS344196 is an antibody targeting CDX-2. Also known as Monoclonal Rabbit Anti-Human CDX-2 Antibody. Host: Rabbit.