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LMO2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS344063

Intended Use: The LMO2 [IHC615] antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test… More details

$245 / 0.1 mL (Concentrate) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LMO2, Monoclonal Antibody
Full Product Name
LMO2
Product Gene Name
anti-LMO2 antibody
Clonality
Monoclonal
Host
Mouse
Species Reactivity
Human
Form/Format
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Preparation and Storage
Store at 2-8 degree C. Do not freeze.
To ensure proper stability and delivery of the antibody after each run, replace the cap and immediately place the bottle in a refrigerator in an upright position.
Positive and negative controls should be simultaneously run with unknown specimens.
Molecular Weight
25,036 Da
Positive Control
Tonsil, Follicular Lymphoma, Diffuse Large B-Cell Lymphoma
Principles and Procedures
Visualization of the antigen present in tissue sections is accomplished in a multi-step immunohistochemical staining process, in conjunction with a horseradish peroxidase (HRP) or alkaline phosphatase (AP) linked detection system. The process involves the addition of the stated antibody (primary antibody) to a tissue slide, followed by a secondary antibody (linked to an enzyme complex) which specifically binds to the primary antibody. A chromogenic substrate is then added which reacts with the enzyme complex, resulting in a colorimetric reaction at the site of the antigen. Results are interpreted using a light microscope.
Reconstitution
The prediluted antibody does not require any mixing, dilution, reconstitution, or titration; the antibody is ready-to-use and optimized for staining.
The concentrated antibody requires dilution in the optimized buffer, to the recommended working dilution range.
Specimen Collection and Preparation for Analysis
Each tissue section should be fixed with 10% neutral buffered formalin, cut to the applicable thickness (4um), and placed on a glass slide that is positively charged. The prepared slide may then be baked for a minimum of 30 minutes in a 53-65 degree C oven (do not exceed 24 hours).
Note: Performance evaluation has been shown on human tissues only. Variable results may occur due to extended fixation time or special processes of specific tissue preparations.
Application Notes for anti-LMO2 antibody
The recommended working dilution range is 1:100 - 1:200.

Immunohistochemistry (IHC) of anti-LMO2 antibody

LMO2 [IHC615] on Tonsil
Mouse Anti-LMO2 Monoclonal Antibody – Cat# MBS344063

Product References and Citations for anti-LMO2 antibody

1. Fouad-Younes S, et al. Am J Surg Pathol. 2010; 34:1266-76.
2. Natkunam Y, et al. Blood. 2007; 109:1636-42.

Other Notes

Small volumes of anti-LMO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LMO2 purchase

MBS344063 is an antibody targeting LMO2. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for LMO2. It may not necessarily be applicable to this product.

NCBI GI #
49256403
NCBI GeneID
4005
NCBI Accession #
AAH73973.1
UniProt Secondary Accession #
Q9HD58
UniProt Related Accession #
P25791
NCBI Official Full Name
LMO2 protein
NCBI Official Synonym Full Names
LIM domain only 2
NCBI Official Symbol
LMO2
NCBI Official Synonym Symbols
TTG2; LMO-2; RBTN2; RHOM2; RBTNL1
UniProt Protein Name
Rhombotin-2
UniProt Synonym Protein Names
Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; T-cell translocation protein 2
Protein Family
Rhombotin
UniProt Gene Name
LMO2
UniProt Synonym Gene Names
RBTN2; RBTNL1; RHOM2; TTG2; LMO-2
NCBI Protein Information
rhombotin-2

NCBI Summary for LMO2

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
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UniProt Comments for LMO2

Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

Research Articles on LMO2

1. the data in this study revealed a novel crosstalk between LMO2 and the Wnt signaling pathway during tumorigenesis and suggested that LMO2 might be a tumor suppressor in certain solid tumors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LMO2 antibody

 Reference Product  PubMed Publications
 TAL1 antibody  >119 publications with LMO2 and TAL1
 LDB1 antibody  >60 publications with LMO2 and LDB1
 GATA1 antibody  >58 publications with LMO2 and GATA1
 GATA2 antibody  >40 publications with LMO2 and GATA2
 BMP4 antibody  >4 publications with LMO2 and BMP4
 RLIM antibody  >2 publications with LMO2 and RLIM
 ELF2 antibody  >1 publications with LMO2 and ELF2
 BEX1 antibody  >1 publications with LMO2 and BEX1
 KDM5A antibody  >1 publications with LMO2 and KDM5A
 BEX2 antibody  >1 publications with LMO2 and BEX2

Pathways associated with anti-LMO2 antibody

 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with anti-LMO2 antibody

 Disease Name  Pubmed Publications
 Leukemia, T-Cell Antibodies  >121 publications with LMO2 and Leukemia, T-Cell
 Lymphoma Antibodies  >119 publications with LMO2 and Lymphoma
 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >32 publications with LMO2 and Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
 Cell Transformation, Neoplastic Antibodies  >22 publications with LMO2 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >21 publications with LMO2 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >12 publications with LMO2 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >7 publications with LMO2 and Nervous System Diseases
 Kidney Diseases Antibodies  >5 publications with LMO2 and Kidney Diseases
 Inflammation Antibodies  >4 publications with LMO2 and Inflammation
 Prostatic Neoplasms Antibodies  >4 publications with LMO2 and Prostatic Neoplasms

Organs/Tissues associated with anti-LMO2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >176 publications with LMO2 and Blood
 Bone Antibodies  >53 publications with LMO2 and Bone
 Vascular Antibodies  >46 publications with LMO2 and Vascular
 Bone Marrow Antibodies  >40 publications with LMO2 and Bone Marrow
 Embryonic Tissue Antibodies  >27 publications with LMO2 and Embryonic Tissue
 Liver Antibodies  >22 publications with LMO2 and Liver
 Kidney Antibodies  >16 publications with LMO2 and Kidney
 Lymph Node Antibodies  >15 publications with LMO2 and Lymph Node
 Heart Antibodies  >12 publications with LMO2 and Heart
 Brain Antibodies  >10 publications with LMO2 and Brain
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