Mouse Anti-TTF-1 Monoclonal Antibody – Cat# MBS344101

TTF-1 [IHC414] on Thyroid Gland

TTF-1 Antibody – Mouse Monoclonal

Name: TTF-1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS344101
Price: 200 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS344101

Thyroid Transcription Factor 1 (TTF-1) is present in diencephalon, lung, and thyroid. Anti-TTF-1 stains thyroid and thyroid-derived tumors, and is therefore used for distinguishing lung adenocarcinoma from germ cell tumors, malignant mesothelioma, and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TTF-1, Monoclonal Antibody

Full Product Name

TTF-1 Antibody

Product Gene Name

anti-TTF-1 antibody

Clonality

Monoclonal

Host

Mouse

Species Reactivity

Human

OMIM

X83973 mRNA

3D Structure

ModBase 3D Structure for Q15361

Positive Control

Lung Adenocarcinoma

Application Notes for anti-TTF-1 antibody

Dilution Range: 1:100 - 1:400

Product References and Citations for anti-TTF-1 antibody

1. Bejarano PA, et al. Mod Pathol. 1996; 9:445-52. 2. Holzinger A, et al. Hybridoma. 1996; 15:49-53. 3. Saad RS, et al. Appl Immunohistochem Mol Morphol. 2003; 11:107-12. 4. Di Loreto C, et al. Cancer Lett. 1998; 124:73-8. 5. Abutaily AS, et al. J Clin Pathol. 2002; 55:662-8. 6. Di Loreto C, et al. J Clin Pathol. 1997; 50:30-2. 7. Katoh R, et al. Mod Pathol. 2000; 13:570-6. 8. Jang KY, et al. Anal Quant Cytol Histol. 2001; 23:400-4. 9. Srodon M, et al. Hum Pathol. 2002; 33:642-5.

Other Notes

Small volumes of anti-TTF-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TTF-1 purchase

MBS344101 is an antibody targeting TTF-1. Also known as TTF-1 Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TTF-1. It may not necessarily be applicable to this product.

NCBI GI #

33356179

NCBI GeneID

7270

NCBI Accession #

NP_031370.2

UniProt Primary Accession #

Q15361

UniProt Related Accession #

Q15361

GenBank Nucleotide #

NM_007344.4

NCBI Official Full Name

transcription termination factor 1 isoform 1

NCBI Official Synonym Full Names

transcription termination factor 1

NCBI Official Symbol

TTF1

NCBI Official Synonym Symbols

TTF-1; TTF-I

UniProt Protein Name

Transcription termination factor 1

UniProt Synonym Protein Names

RNA polymerase I termination factor; Transcription termination factor I; TTF-I

Protein Family

Thyroid transcription factor

UniProt Gene Name

TTF1

UniProt Synonym Gene Names

TTF-1; TTF-I

NCBI Protein Information

transcription termination factor 1

NCBI Summary for TTF-1

This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]

UniProt Comments for TTF-1

Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.

Research Articles on TTF-1

1. TTF1 expression is an independent predictor of survival of patients with advanced lung adenocarcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TTF-1 antibody

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Disease Pathway antibodies	Disease Pathway Diagram
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Diseases Of Metabolism Pathway antibodies	Diseases Of Metabolism Pathway Diagram
ERCC6 (CSB) And EHMT2 (G9a) Positively Regulate RRNA Expression Pathway antibodies	ERCC6 (CSB) And EHMT2 (G9a) Positively Regulate RRNA Expression Pathway Diagram
Epigenetic Regulation Of Gene Expression Pathway antibodies	Epigenetic Regulation Of Gene Expression Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Human Thyroid Stimulating Hormone (TSH) Signaling Pathway antibodies	Human Thyroid Stimulating Hormone (TSH) Signaling Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Negative Epigenetic Regulation Of RRNA Expression Pathway antibodies	Negative Epigenetic Regulation Of RRNA Expression Pathway Diagram