Mouse Anti-NGFR Monoclonal Antibody – Cat# MBS346023

IHC (paraffin) of human cervix using Nerve Growth Factor Receptor (NGFR) Antibody

Nerve Growth Factor Receptor (NGFR) Antibody – Mouse Monoclonal

Name: NGFR Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS346023
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS346023

NGFR (Nerve Growth Factor Receptor) is a receptor in the tumor necrosis receptor family. NGFR can often be found in Schwann cells and neurons, as well as a plethora of non-neuronal cells that regulate neuron growth, migration, differentiation, and cell… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Nerve Growth Factor Receptor (NGFR), Monoclonal Antibody

Full Product Name

Nerve Growth Factor Receptor (NGFR) Antibody

Product Gene Name

anti-NGFR antibody

Clonality

Monoclonal

Isotype

IgG

Clone Number

IHC637

Host

Mouse

Species Reactivity

Human

Form/Format

Liquid

Preparation and Storage

Store at 2-8 degree C. Do not freeze.

Molecular Weight

35,767 Da

Buffer

Tris Buffer, ph7.4, 1% BSA, <0.1% NaN3

IHC Positive Control

Breast

IHC Suggested Protocol

1. Tissues are fixed with 10% neutral buffered formalin, cut to ~4um, and placed on a positively charged glass slide.
2. The prepared slide is baked for at least 30 minutes and at most 24 hours at 55-65 degree C.
3. Pretreatment - Perform heat-induced epitope retrieval (HIER) at pH 6 for 10 to 30 minutes.
4. Block – Block with peroxidase solution for 5 minutes at RT.
5. Primary Ab – Dilute antibodies 1:100 – 1:200 and incubate for 10 - 30 minutes at RT.
6. Secondary Ab - Incubate for 20 - 30 minutes at RT.
7. Substrate - Incubate DAB or Fast Red for 5 - 10 minutes at RT.
8. Counterstain - Counterstain with hematoxylin for 30 seconds to 5 minutes, rinse with distilled water and blueing solution for 30 seconds.
9. Dehydrate and apply coverslip.
(Each researcher should optimize the protocol for their experimental model system.)

Applications Tested/Suitable for anti-NGFR antibody

Immunohistochemistry (IHC) Paraffin

Application Notes for anti-NGFR antibody

Dilution Range: 1:100 - 1:200

Other Notes

Small volumes of anti-NGFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NGFR purchase

MBS346023 is an antibody targeting NGFR. Also known as Nerve Growth Factor Receptor (NGFR) Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for NGFR. It may not necessarily be applicable to this product.

NCBI GI #

189205

NCBI GeneID

4804

NCBI Accession #

AAB59544.1

UniProt Secondary Accession #

B2R961; B4E096

UniProt Related Accession #

P08138

NCBI Official Full Name

nerve growth factor receptor

NCBI Official Synonym Full Names

nerve growth factor receptor

NCBI Official Symbol

NGFR

NCBI Official Synonym Symbols

CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 16

UniProt Synonym Protein Names

Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD_antigen: CD271

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

NGFR

UniProt Synonym Gene Names

TNFRSF16; NGF receptor

NCBI Protein Information

tumor necrosis factor receptor superfamily member 16

NCBI Summary for NGFR

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

UniProt Comments for NGFR

Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.

Research Articles on NGFR

1. High p75(NTR) expression is associated with esophageal squamous cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NGFR antibody

Reference Product	PubMed Publications
NGF antibody	>288 publications with NGFR and NGF
BDNF antibody	>74 publications with NGFR and BDNF
NTRK1 antibody	>19 publications with NGFR and NTRK1
NTRK2 antibody	>15 publications with NGFR and NTRK2
NTF3 antibody	>5 publications with NGFR and NTF3
RTN4R antibody	>4 publications with NGFR and RTN4R
SORT1 antibody	>3 publications with NGFR and SORT1
RIPK2 antibody	>2 publications with NGFR and RIPK2
ARHGDIA antibody	>1 publications with NGFR and ARHGDIA

Pathways associated with anti-NGFR antibody

Products by Pathway	Pathway Diagram
Apoptosis - Multiple Species Pathway antibodies	Apoptosis - Multiple Species Pathway Diagram
Apoptosis - Multiple Species Pathway antibodies	Apoptosis - Multiple Species Pathway Diagram
Axonal Growth Inhibition (RHOA Activation) Pathway antibodies	Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
Axonal Growth Stimulation Pathway antibodies	Axonal Growth Stimulation Pathway Diagram
Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway antibodies	Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
Ceramide Signalling Pathway antibodies	Ceramide Signalling Pathway Diagram
Circadian Rythm Related Genes Pathway antibodies	Circadian Rythm Related Genes Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with anti-NGFR antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>154 publications with NGFR and Nervous System Diseases
Brain Diseases Antibodies	>83 publications with NGFR and Brain Diseases
Necrosis Antibodies	>55 publications with NGFR and Necrosis
Neurodegenerative Diseases Antibodies	>51 publications with NGFR and Neurodegenerative Diseases
Disease Models, Animal Antibodies	>47 publications with NGFR and Disease Models, Animal
Inflammation Antibodies	>43 publications with NGFR and Inflammation
Nerve Degeneration Antibodies	>39 publications with NGFR and Nerve Degeneration
Breast Neoplasms Antibodies	>27 publications with NGFR and Breast Neoplasms
Pain Antibodies	>25 publications with NGFR and Pain
Cardiovascular Diseases Antibodies	>20 publications with NGFR and Cardiovascular Diseases