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PMS2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS346029

PMS2 (Postmeiotic Segregation Increased 2) is part of the mismatch-repair pathway, often associated with hereditary non-polyposis colorectal cancer. Mutations to this protein have shown to be correlated with the development of sporadic colorectal carcinoma.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PMS2, Monoclonal Antibody
Full Product Name
PMS2 Antibody
Product Gene Name
anti-PMS2 antibody
Clonality
Monoclonal
Isotype
IgG
Clone Number
IHC412
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid
Preparation and Storage
Store at 2-8 degree C. Do not freeze.
Buffer
Tris Buffer, ph7.4, 1% BSA, <0.1% NaN3
IHC Positive Control
Colon
IHC Suggested Protocol
1. Tissues are fixed with 10% neutral buffered formalin, cut to ~4um, and placed on a positively charged glass slide.
2. The prepared slide is baked for at least 30 minutes and at most 24 hours at 55-65 degree C.
3. Pretreatment - Perform heat-induced epitope retrieval (HIER) at pH 6 for 10 to 30 minutes.
4. Block – Block with peroxidase solution for 5 minutes at RT.
5. Primary Ab – Dilute antibodies 1:100 – 1:200 and incubate for 10 - 30 minutes at RT.
6. Secondary Ab - Incubate for 20 - 30 minutes at RT.
7. Substrate - Incubate DAB or Fast Red for 5 - 10 minutes at RT.
8. Counterstain - Counterstain with hematoxylin for 30 seconds to 5 minutes, rinse with distilled water and blueing solution for 30 seconds.
9. Dehydrate and apply coverslip.
(Each researcher should optimize the protocol for their experimental model system.)
Applications Tested/Suitable for anti-PMS2 antibody
Immunohistochemistry (IHC) Paraffin
Application Notes for anti-PMS2 antibody
Dilution Range: 1:100 - 1:200

Immunohistochemistry (IHC) of anti-PMS2 antibody

IHC (paraffin) of human duodenum using PMS2 Antibody
Mouse Anti-PMS2 Monoclonal Antibody – Cat# MBS346029

Other Notes

Small volumes of anti-PMS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PMS2 purchase

MBS346029 is an antibody targeting PMS2. Also known as PMS2 Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PMS2. It may not necessarily be applicable to this product.

NCBI GI #
17136970
NCBI GeneID
36705
NCBI Accession #
NP_477023.1
GenBank Nucleotide #
NM_057675.4
NCBI Official Full Name
Pms2
NCBI Official Symbol
Pms2
NCBI Official Synonym Symbols
CG8169; DmelCG8169; dmlh-2; dmlh2; dpms2; Mlh2; pms2
Protein Family
Mismatch repair endonuclease
NCBI Protein Information
Pms2

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PMS2 antibody

 Products by Pathway  Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Mismatch Repair Pathway antibodies  Mismatch Repair Pathway Diagram
 Mismatch Repair Pathway antibodies  Mismatch Repair Pathway Diagram
 Mismatch Repair Pathway antibodies  Mismatch Repair Pathway Diagram
 Mismatch Repair (MMR) Directed By MSH2:MSH6 (MutSalpha) Pathway antibodies  Mismatch Repair (MMR) Directed By MSH2:MSH6 (MutSalpha) Pathway Diagram
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