AQP1: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Belongs to the MIP/aquaporin (TC 1.A.8) family.
Protein type: Membrane protein, multi-pass; Transporter; Transporter, aquaporin family; Membrane protein, integral
Cellular Component: nuclear membrane; neuron projection; integral to plasma membrane; basolateral plasma membrane; cell; brush border membrane; integral to membrane; dense core granule membrane; membrane; apical part of cell; axon; cytoplasm; apical plasma membrane; basal plasma membrane; plasma membrane; nerve terminal; nucleus; sarcolemma; brush border
Molecular Function: potassium channel activity; ephrin receptor binding; water transporter activity; intracellular cGMP activated cation channel activity; transporter activity; ammonium transmembrane transporter activity; glycerol transmembrane transporter activity; potassium ion transmembrane transporter activity; transmembrane transporter activity; water channel activity; nitric oxide transporter activity; glycerol channel activity
Biological Process: cGMP biosynthetic process; glycerol transport; wound healing; cellular response to stress; carbon dioxide transport; water transport; negative regulation of caspase activity; sensory perception of pain; positive regulation of saliva secretion; water homeostasis; positive regulation of fibroblast proliferation; organic cation transport; nitric oxide transport; transport; cellular homeostasis; transmembrane transport; potassium ion transport; lipid digestion; secretion by cell; response to drug; cellular water homeostasis; secretory granule organization and biogenesis; glomerular filtration; ammonium transport; positive regulation of angiogenesis; renal water transport; camera-type eye morphogenesis; adrenocorticotropin hormone secretion; establishment and/or maintenance of actin cytoskeleton polarity; cell volume homeostasis; positive regulation of cell migration; negative regulation of apoptosis
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