Urokinase (UK) ELISA Kit for Hamster

Name: Hamster UK ELISA Kit; Urokinase; MyBioSource
Brand: MyBioSource
SKU: MBS035066
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS035066

Background: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used to determine the level of UK (hereafter termed "analyte") in undiluted original… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Urokinase (UK), ELISA Kit

Full Product Name

Hamster Urokinase ELISA Kit

Product Gene Name

UK elisa kit

Species Reactivity

Hamster

Assay Type

Quantitative Sandwich

Detection Range

0.625ng/ml-20ng/ml

Sensitivity

0.1ng/ml

Specificity

No significant cross-reactivity or interference between Hamster UK and analogues was observed.

Preparation and Storage

Store all reagents at 2-8 degree C

Inter-assay Precision

Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Intra-assay Precision

Intra-assay CV (%) is less than 15%.

Molecular Weight

36,978 Da

OMIM

173391

3D Structure

ModBase 3D Structure for Q03405

Other Notes

Small volumes of UK elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UK purchase

MBS035066 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Urokinase (UK) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing UK. The ELISA analytical biochemical technique of the MBS035066 kit is based on UK antibody-UK antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect UK antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, UK. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for UK. It may not necessarily be applicable to this product.

NCBI GI #

4505865

NCBI GeneID

5329

NCBI Accession #

NP_002650.1

UniProt Primary Accession #

Q03405

UniProt Secondary Accession #

Q12876; Q15845; Q16887; Q6IB52; Q9BWT0; Q9NYC8; Q9UD69; Q9UEA6; Q9UM92; Q9UMV0; A8K409

UniProt Related Accession #

Q03405

GenBank Nucleotide #

NM_002659.3

NCBI Official Full Name

urokinase plasminogen activator surface receptor isoform 1

NCBI Official Synonym Full Names

plasminogen activator, urokinase receptor

NCBI Official Symbol

PLAUR

NCBI Official Synonym Symbols

CD87; UPAR; URKR; U-PAR

UniProt Protein Name

Urokinase plasminogen activator surface receptor

UniProt Synonym Protein Names

Monocyte activation antigen Mo3

Protein Family

Urokinase plasminogen activator surface receptor

UniProt Gene Name

PLAUR

UniProt Synonym Gene Names

MO3; UPAR; U-PAR; uPAR

UniProt Entry Name

UPAR_HUMAN

NCBI Protein Information

urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2; urokinase-type plasminogen activator (uPA) receptor

NCBI Summary for UK

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

UniProt Comments for UK

uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, GPI anchor; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: endoplasmic reticulum membrane; focal adhesion; extrinsic to membrane; endoplasmic reticulum lumen; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein domain specific binding; protein binding; enzyme binding; U-plasminogen activator receptor activity; receptor activity; receptor binding

Biological Process: fibrinolysis; cellular protein metabolic process; regulation of proteolysis; attachment of GPI anchor to protein; C-terminal protein lipidation; signal transduction; chemotaxis; blood coagulation; post-translational protein modification; cell motility

Research Articles on UK

1. HIV-1 infected lymphoid organs upregulate expression and release of the cleaved form of uPAR that modulates chemotaxis and virus expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with UK elisa kit

Products by Pathway	Pathway Diagram
Arf6 Downstream Pathway antibodies	Arf6 Downstream Pathway Diagram
Attachment Of GPI Anchor To UPAR Pathway antibodies	Attachment Of GPI Anchor To UPAR Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Dissolution Of Fibrin Clot Pathway antibodies	Dissolution Of Fibrin Clot Pathway Diagram
FGF Signaling Pathway antibodies	FGF Signaling Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway antibodies	Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway Diagram

Diseases associated with UK elisa kit

Disease Name	Pubmed Publications
Neoplasms Antibodies	>816 publications with UK and Neoplasms
Carcinoma Antibodies	>313 publications with UK and Carcinoma
Neoplasm Invasiveness Antibodies	>261 publications with UK and Neoplasm Invasiveness
Neoplasm Metastasis Antibodies	>239 publications with UK and Neoplasm Metastasis
Breast Neoplasms Antibodies	>164 publications with UK and Breast Neoplasms
Inflammation Antibodies	>111 publications with UK and Inflammation
Lung Diseases Antibodies	>90 publications with UK and Lung Diseases
Nervous System Diseases Antibodies	>83 publications with UK and Nervous System Diseases
Cardiovascular Diseases Antibodies	>83 publications with UK and Cardiovascular Diseases
Lung Neoplasms Antibodies	>76 publications with UK and Lung Neoplasms

Organs/Tissues associated with UK elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>504 publications with UK and Blood
Vascular Antibodies	>301 publications with UK and Vascular
Lung Antibodies	>147 publications with UK and Lung
Muscle Antibodies	>98 publications with UK and Muscle
Brain Antibodies	>86 publications with UK and Brain
Liver Antibodies	>83 publications with UK and Liver
Embryonic Tissue Antibodies	>80 publications with UK and Embryonic Tissue
Bone Antibodies	>80 publications with UK and Bone
Kidney Antibodies	>75 publications with UK and Kidney
Prostate Antibodies	>65 publications with UK and Prostate