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PCNA Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS355048

Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase delta in eukaryotic cells. This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic… More details

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Product Overview

Product Name
PCNA pAb, Antibody
Full Product Name
PCNA antibody
Product Gene Name
anti-PCNA antibody
Product Synonym Names
Polyclonal Anti- PCNA
Host
Rabbit
Species Reactivity
Human, mouse, rat, monkey, Chinese hamster, dog
Form/Format
Liquid
Specificity
Detect the endogenous levels of total PCNA protein.
Preparation and Storage
Store at -20 degree C for 1 year. Avoid repeated freeze and thaw cycles
Molecular Weight
28,706 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (5095599..5107268, complement). Location: 20pter-p12
3D Structure
ModBase 3D Structure for Q6FHF5
Immunogen
A synthetic peptide corresponding to internal residues of human PCNA.

Product Categories/Family for anti-PCNA antibody

Loading Control Antibodies
Applications Tested/Suitable for anti-PCNA antibody
Western Blot (WB)
Application Notes for anti-PCNA antibody
WB (Hu, Mk, M, R, ChHm, Dog)

Product References and Citations for anti-PCNA antibody

1. Bowman GD, O'Donnell M, Kuriyan J (2004). "Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex". Nature 429 (6993): 724-730. 2. Burkovics P., Hajdu I., Szukacsov V., Unk I., Haracska L."Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage." Nucleic Acids Res. 37:4247-4255(2009) 3. Motegi A., Liaw H.-J., Lee K.-Y., Roest H.P., Maas A., Wu X., Moinova H., Markowitz S.D., Ding H., Hoeijmakers J.H.J., Myung K. "Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks." Proc. Natl. Acad. Sci. U.S.A. 105:12411-12416(2008)

Other Notes

Small volumes of anti-PCNA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PCNA purchase

MBS355048 is an antibody targeting PCNA. Also known as PCNA antibody. Reactive in Human, mouse, rat, monkey, Chinese hamster, dog. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PCNA. It may not necessarily be applicable to this product.

NCBI GI #
49456555
NCBI GeneID
5111
NCBI Accession #
CAG46598.1
UniProt Primary Accession #
Q6FHF5
UniProt Related Accession #
P12004
NCBI Official Full Name
PCNA
NCBI Official Synonym Full Names
proliferating cell nuclear antigen
NCBI Official Symbol
PCNA
UniProt Protein Name
Proliferating cell nuclear antigen
Protein Family
Probable DNA polymerase sliding clamp
UniProt Gene Name
PCNA
UniProt Entry Name
Q6FHF5_HUMAN
NCBI Protein Information
proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein

NCBI Summary for PCNA

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
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UniProt Comments for PCNA

Function: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand

By similarity.

Subcellular location: Nucleus

By similarity.

Sequence similarities: Belongs to the PCNA family. RuleBase RU003671
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Research Articles on PCNA

1. Novel interaction between proliferating cell nuclear antigen and HLA I on the surface of tumor cells inhibits NK cell function through NKp44.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PCNA antibody

 Products by Pathway  Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram

Organs/Tissues associated with anti-PCNA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2423 publications with PCNA and Blood
 Liver Antibodies  >1872 publications with PCNA and Liver
 Vascular Antibodies  >1857 publications with PCNA and Vascular
 Muscle Antibodies  >1596 publications with PCNA and Muscle
 Brain Antibodies  >1024 publications with PCNA and Brain
 Kidney Antibodies  >971 publications with PCNA and Kidney
 Lung Antibodies  >899 publications with PCNA and Lung
 Skin Antibodies  >812 publications with PCNA and Skin
 Bone Antibodies  >753 publications with PCNA and Bone
 Lymph Antibodies  >639 publications with PCNA and Lymph
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