CD105 / ENDOGLIN Antibody – Rabbit Polyclonal

Endoglin (CD105) is a cell surface component of the transforming growth factor-beta (TGF-beta) receptor complex highly expressed by endothelial cells. It may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. Mutations in the endoglin gene are responsible for the hereditary hemorrhagic telangiectasia type 1 (HHT1), also known as Osler-Weber-Rendu syndrome.1 This gene also plays an important role in cardiovascular development and vascular remodeling.2 Endoglin levels have been found to be elevated in pregnant women who subsequently develop preeclampsia.3

1. Rius, C., Smith, J. D., Almendro, N., Langa, C., Botella, L. M., Marchuk, D. A., Vary, C. P. H., Bernabeu, C. Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1. Blood 92: 4677-4690, 1998. 2. Sanz-Rodriguez, Francisco; Mercedes Guerrero-Esteo, Luisa-Maria Botella, Denis Banville (2004). "Endoglin Regulates Cytoskeletal Organization through Binding to ZRP-1, a Member of the Lim Family of Proteins". J. Biol. Chem. 279 (31): 32858-68. 3. Venkatesha, S; Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. (2006). "Soluble endoglin contributes to the pathogenesis of preeclampsia". Nat Med 12 (6): 642-9.

Small volumes of anti-CD105 / Endoglin antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS355054 is an antibody targeting CD105 / Endoglin. Reactive in Mouse. Host: Rabbit.