Mouse Anti-CgA Polyclonal Antibody – Cat# MBS355062

Chromogranin-A, Cga (CgA) Antibody – Mouse Polyclonal

Name: CgA Antibody; Polyclonal; Mouse; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS355062
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS355062

Chromogranin A (CgA), also called parathyroid secretory protein 1, is a member of the granin family of neuroendocrine secretory proteins. It is located in secretory vesicles of neurons and endocrine cells. Chromogranin A gene has 8 exons and 7 introns… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Chromogranin-A, CgA, Polyclonal Antibody

Full Product Name

Anti-Chromogranin-A, CgAa antibody

Product Gene Name

anti-CgA antibody

Product Synonym Names

Monoclonal Anti- Chromogranin-A; CgA

Clonality

Polyclonal

Isotype

IgG2a

Clone Number

S27-1

Host

Mouse

Species Reactivity

Human, mouse, rat

Form/Format

Liquid

Purity/Purification

Cultured cell supernatant, Protein A purified

Preparation and Storage

Store at 4 degree C after thawing (1 week). Aliquot and store at -20 degree C for long term (at least one year). Avoid repeated freeze and thaw cycles

Molecular Weight

50,688 Da

Chromosome Location

Chromosome: 14; NC_000014.8 (93389445..93401638). Location: 14q32

OMIM

118910

3D Structure

ModBase 3D Structure for P10645

Immunogen

A synthetic peptide (conjugated with KLH) corresponding to the C-terminal of human CgA.

Storage Buffer

In TBS (pH7.4), 0.5% BSA, 25% Glycerol and 0.05% Sodium Azide.

Applications Tested/Suitable for anti-CgA antibody

Western Blot (WB)

Application Notes for anti-CgA antibody

WB (1:2000)

Product References and Citations for anti-CgA antibody

1. Wu, H.-J., Rozansky, D. J., Parmer, R. J., Gill, B. M., O'Connor, D. T. Structure and function of the chromogranin A gene: clues to evolution and tissue-specific expression. J. Biol. Chem. 266: 13130-13134, 1991. 2. Cotesta D, Caliumi C, Alò P, Petramala L, Reale MG, Masciangelo R, Signore A, Cianci R, D'Erasmo E, Letizia C (2005). "High plasma levels of human chromogranin A and adrenomedullin in patients with pheochromocytoma". Tumori 91 (1): 53-8. 3. Wu JT, Erickson AJ, Tsao KC, Wu TL, Sun CF (April 2000). "Elevated serum chromogranin A is detectable in patients with carcinomas at advanced disease stages". Ann. Clin. Lab. Sci. 30 (2): 175-8. 4. Nikou GC, Lygidakis NJ, Toubanakis C, Pavlatos S, Tseleni-Balafouta S, Giannatou E, Mallas E, Safioleas M (2005). "Current diagnosis and treatment of gastrointestinal carcinoids in a series of 101 patients: the significance of serum chromogranin-A, somatostatin receptor scintigraphy and somatostatin analogues". Hepatogastroenterology 52 (63): 731-41.

Other Notes

Small volumes of anti-CgA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CgA purchase

MBS355062 is an antibody targeting CgA. Also known as Anti-Chromogranin-A, CgAa antibody. Reactive in Human, mouse, rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CgA. It may not necessarily be applicable to this product.

NCBI GI #

4502805

NCBI GeneID

1113

NCBI Accession #

NP_001266.1

UniProt Primary Accession #

P10645

UniProt Secondary Accession #

Q53FA8; Q6NR84; Q96E84; Q96GL7; Q9BQB5; B2R9E9

UniProt Related Accession #

P10645

GenBank Nucleotide #

NM_001275.3

NCBI Official Full Name

chromogranin-A preproprotein

NCBI Official Synonym Full Names

chromogranin A (parathyroid secretory protein 1)

NCBI Official Symbol

CHGA

NCBI Official Synonym Symbols

CGA

UniProt Protein Name

Chromogranin-A

UniProt Synonym Protein Names

Pituitary secretory protein I; SP-ICleaved into the following 13 chains:Vasostatin-1; Alternative name(s):; Vasostatin IVasostatin-2; Alternative name(s):; Vasostatin II

Protein Family

Glycoprotein hormones

UniProt Gene Name

CHGA

UniProt Synonym Gene Names

CgA; SP-I

UniProt Entry Name

CMGA_HUMAN

NCBI Protein Information

chromogranin-A; SP-I; pituitary secretory protein I; parathyroid secretory protein 1; betagranin (N-terminal fragment of chromogranin A)

NCBI Summary for CgA

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008]

UniProt Comments for CgA

Function: Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.

Subunit structure: Interacts with SCG3

By similarity.

Subcellular location: Cytoplasmic vesicle › secretory vesicle lumen

By similarity. Cytoplasmic vesicle › secretory vesicle membrane

By similarity. Secreted. Note: Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions

By similarity.

Post-translational modification: Sulfated on tyrosine residues and/or contains sulfated glycans.O-glycosylated with core 1 or possibly core 8 glycans. Ref.16 Ref.20

Miscellaneous: Binds calcium with a low-affinity.

Sequence similarities: Belongs to the chromogranin/secretogranin protein family.

Research Articles on CgA

1. Data suggest that multi-antibody assay of TTF1, Vimentin, p63 CD56, chromogranin and synaptophysin may be of special value, especially in diagnosing small biopsies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CgA antibody

Reference Product	PubMed Publications
SYP antibody	>6 publications with CgA and SYP
SCG2 antibody	>3 publications with CgA and SCG2
CALM1 antibody	>1 publications with CgA and CALM1
IGF1 antibody	>1 publications with CgA and IGF1
SCG3 antibody	>1 publications with CgA and SCG3

Diseases associated with anti-CgA antibody

Disease Name	Pubmed Publications
Pheochromocytoma Antibodies	>62 publications with CgA and Pheochromocytoma
Hypertension Antibodies	>58 publications with CgA and Hypertension
Cardiovascular Diseases Antibodies	>50 publications with CgA and Cardiovascular Diseases
Nervous System Diseases Antibodies	>45 publications with CgA and Nervous System Diseases
Brain Diseases Antibodies	>34 publications with CgA and Brain Diseases
Hyperplasia Antibodies	>28 publications with CgA and Hyperplasia
Kidney Diseases Antibodies	>24 publications with CgA and Kidney Diseases
Carcinoma, Non-Small-Cell Lung Antibodies	>23 publications with CgA and Carcinoma, Non-Small-Cell Lung
Liver Diseases Antibodies	>18 publications with CgA and Liver Diseases
Necrosis Antibodies	>10 publications with CgA and Necrosis

Organs/Tissues associated with anti-CgA antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>102 publications with CgA and Nerve
Adrenal Gland Antibodies	>79 publications with CgA and Adrenal Gland
Prostate Antibodies	>53 publications with CgA and Prostate
Stomach Antibodies	>48 publications with CgA and Stomach
Lung Antibodies	>48 publications with CgA and Lung
Brain Antibodies	>45 publications with CgA and Brain
Thyroid Antibodies	>42 publications with CgA and Thyroid
Pancreas Antibodies	>33 publications with CgA and Pancreas
Parathyroid Antibodies	>28 publications with CgA and Parathyroid
Kidney Antibodies	>26 publications with CgA and Kidney