Cytokeratin 18, CK18 (CK18) Antibody – Mouse Polyclonal

Cytokeratin 18, also known as keratin 18 (K18), is a type I cytokeratin. The K18 gene is 3791 bp in length and the K18 protein is coded for by seven exons.1 Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.2 Keratin 8 and 18 (K8/18) are the major components of intermediate filament (IF) proteins of simple or single-layered epithelia.3

1. Kulesh, D. A., Oshima, R. G. Complete structure of the gene for human keratin 18. Genomics 4: 339-347, 1989.2. W. Jeffrey Allard, Jeri Matera, M. Craig Miller, et al. (October 2004). "Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases". Clin. Cancer Research 10 (20): 6897-6904. 3. Inada, H; Izawa I, Nishizawa M, Fujita E, Kiyono T, Takahashi T, Momoi T, Inagaki M (Oct. 2001). "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD". J. Cell Biol. (United States) 155 (3): 415-26.

Small volumes of anti-CK18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS355087 is an antibody targeting CK18. Also known as Anti-Cytokeratin 18, CK18 antibody. Reactive in Mouse, rat, human. Host: Mouse.