Heat Shock Protein 60, HSP60 (HSP60) Antibody – Mouse Monoclonal

Heat shock protein 60 (HSP60) in the matrix of mitochondria is essential for the folding and assembly of newly imported proteins. Hsp60 belongs to a class of structurally related chaperonins found in organelles of endosymbiotic origin and in the bacterial cytosol.1 Members of the chaperonin class include the Escherichia coli, groEL protein and the Rubisco subunit-binding protein of chloroplasts.2 In both prokaryotic and eukaryotic systems, synthesis of these proteins is induced in response to stresses, such as heat shock.3 Under normal physiological conditions, HSP60 is a 60 KD oligomer composed of monomers that form a complex arranged as two stacked heptameric rings.1 HSP60 may be a very useful marker for patients with superficial bladder carcinoma and may be used for predicting disease progression. And low HSP60 expression levels may be usable as a prognostic marker to identify patients for whom local treatment would be insufficient.4 HSP60 also linked to diabetes, cancer and certain types of immunological disorders.

1. Cheng MY, Hartl FU, Horwich AL (November 1990). "The mitochondrial chaperonin hsp60 is required for its own assembly". Nature 348 (6300): 455-8. 2. Cheng, M. Y., Hartl, F.-U., Martin, J., Pollock, R. A., Kalousek, F., Neupert, W., Hallberg, E. M., Hallberg, R. L., Horwich, A. L. Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature 337: 620-625, 1989. 3. Venner, T. J., Singh, B., Gupta, R. S. Nucleotide sequences and novel structural features of human and Chinese hamster hsp60 (chaperonin) gene families. DNA Cell Biol. 9: 545-552, 1990. 4. Lebret T, Watson RW, Molinié V, et al. (September 2003). "Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma". Cancer 98 (5): 970-7.

Small volumes of anti-HSP60 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS355099 is an antibody targeting HSP60. Also known as Anti-Heat shock protein 60, HSP60 antibody. Reactive in Human, mouse. Host: Mouse.