Kinase D-Interacting Substrate 220, Kidins 220 (KIDINS220) Antibody – Mouse Polyclonal

Function: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration

By similarity. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. Ref.6

Subunit structure: Interacts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Can form a ternary complex with NGFR and NTRK1 and this complex is affected by the expression levels of KIDINS220/ARMS. An increase in KIDINS220/ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with SNTA1 and SNTB2 and binds to their PDZ domains. Interacts with EPHA4 and PRKD1

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein

Potential.

Tissue specificity: Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines. Ref.6

Domain: The transmembrane domain mediates interaction with NTRK1

By similarity.

Post-translational modification: Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF)

By similarity.

Sequence similarities: Contains 12 ANK repeats.Contains 1 KAP NTPase domain.

Sequence caution: The sequence BAA86564.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB14728.1 differs from that shown. Reason: Erroneous initiation.