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LAG1 Longevity Assurance Homolog 2, LASS2 (LASS2) Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS355148

Lass2 (LAG1 longevity assurance homolog 2) is a protein that in humans is encoded by the LASS2 gene.[1] It has sequence similarity to yeast longevity assurance gene 1. And it is highly expressed in liver and kidney, which is very different from the expression… More details

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Product Overview

Product Name
LAG1 longevity assurance homolog 2, LASS2, Polyclonal Antibody
Full Product Name
Anti-LAG1 longevity assurance homolog 2, LASS2 antibody
Product Gene Name
Product Synonym Names
Monoclonal Anti- LAG1 longevity assurance homolog 2; LASS2
Clonality
Polyclonal
Isotype
IgG2b
Clone Number
N39
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Protein A or Protein G purified
Preparation and Storage
Store at 4 degree C after thawing (1 week). Aliquot and store at -20 degree C for long term (at least one year). Avoid repeated freeze and thaw cycles.
Molecular Weight
44,876 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (150937649..150947479, complement). Location: 1q21.3
OMIM
606920
3D Structure
ModBase 3D Structure for Q96G23
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to the extracellular region of human LASS2.
Storage Buffer
In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.
Applications Tested/Suitable for anti-LASS2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)
Application Notes for anti-LASS2 antibody
WB (1:500-1000)

Western Blot (WB) of anti-LASS2 antibody

Mouse Anti-LASS2 Polyclonal Antibody – Cat# MBS355148

Product References and Citations for anti-LASS2 antibody

1. Pan H, Qin WX, Huo KK, Wan DF, Yu Y, Xu ZG, Hu QD, Gu KT, Zhou XM, Jiang HQ, Zhang PP, Huang Y, Li YY, Gu JR (Sep 2001). "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1". Genomics 77 (1-2): 58-64.

Other Notes

Small volumes of anti-LASS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LASS2 purchase

MBS355148 is an antibody targeting LASS2. Also known as Anti-LAG1 longevity assurance homolog 2, LASS2 antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for LASS2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
LAG1 longevity assurance homolog 2 (S. cerevisiae), isoform CRA_a
NCBI Official Synonym Full Names
ceramide synthase 2
NCBI Official Symbol
CERS2
NCBI Official Synonym Symbols
L3; LASS2; SP260; TMSG1
UniProt Protein Name
Ceramide synthase 2
UniProt Synonym Protein Names
LAG1 longevity assurance homolog 2; SP260; Tumor metastasis-suppressor gene 1 protein
UniProt Gene Name
CERS2
UniProt Synonym Gene Names
LASS2; TMSG1; CerS2
UniProt Entry Name
CERS2_HUMAN
NCBI Protein Information
ceramide synthase 2; LAG1 longevity assurance 2; LAG1 homolog, ceramide synthase 2; tumor metastasis-suppressor gene 1 protein; longevity assurance (LAG1, S. cerevisiae) homolog 2

NCBI Summary for LASS2

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for LASS2

Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.

Subunit structure: Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR. Ref.1 Ref.15

Subcellular location: Nucleus membrane; Multi-pass membrane protein

Potential. Endoplasmic reticulum membrane; Multi-pass membrane protein

By similarity.

Tissue specificity: Expressed in kidney, liver, brain, heart, placenta and lung. Ref.1

Sequence similarities: Contains 1 homeobox DNA-binding domain.Contains 1 TLC (TRAM/LAG1/CLN8) domain.

Sequence caution: The sequence BAA91505.1 differs from that shown. Reason: Erroneous initiation.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LASS2 antibody

 Reference Product  PubMed Publications
 ATP6V0C antibody  >1 publications with LASS2 and ATP6V0C
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