Protocadherin Fat 1 (FAT1) Antibody – Rabbit Polyclonal

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]

Function: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact

By similarity.

Subunit structure: Interacts (via the C-terminus 4300-4400 AA) with ATN1. Interacts with RERE. Interacts (via EVH1 domains) with ENAH

By similarity. Interacts (via cytoplasmic domain) with CTNNB1

By similarity. Ref.5

Subcellular location: Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm › perinuclear region Ref.3.

Tissue specificity: Expressed in many epithelial and some endothelial and smooth muscle cells.

Domain: A PTB-like motif (DNXYH sequence) is required for the targeting to the leading edge. This motif represents a minimal protein-protein interaction core motif that is not regulated by tyrosine phosphorylation

By similarity.

Post-translational modification: Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus. Ref.3

Sequence similarities: Contains 33 cadherin domains.Contains 5 EGF-like domains.Contains 1 laminin G-like domain.