Cytokeratin 17, CK17 (CK17) Antibody – Mouse Polyclonal

Cytokeratin 17, also known as Keratin, type I cytoskeletal 17 (K17) is a protein that in humans is encoded by the KRT17 gene. Keratin 17 (K17) is a differentiation-specific keratin expressed in the nail bed, hair follicle, sebaceous gland and other epidermal appendages.1 The KRT17 gene is 5 kb long with 8 exons. Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. Cytokeratin 17 synthesis seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells".2

1. Covello, S. P., Smith, F. J. D., Sillevis Smitt, J. H., Paller, A. S., Munro, C. S., Jonkman, M. F., Uitto, J., McLean, W. H. I. Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2. Brit. J. Derm. 139: 475-480, 1998. 2. Troyanovsky, S. M., Leube, R. E., Franke, W. W. Characterization of the human gene encoding cytokeratin 17 and its expression pattern. Europ. J. Cell Biol. 59: 127-137, 1992.

Small volumes of anti-CK17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS355167 is an antibody targeting CK17. Also known as Anti-Cytokeratin 17, CK17 antibody. Reactive in Human, mouse, rat. Host: Mouse.