GATA4 Antibody – Rabbit Polyclonal

Transcription factor GATA-4 is a protein that belongs to the GATA family of zinc finger transcription factors. [1]Members of this family recognize the GATA motif which is present in the promoters of many genes. [2] It is expressed in adult vertebrate heart, gut epithelium, and gonads. [1] This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects as well as reproductive defects.[3] Using rodent and cell culture models, Heineke et al. (2007) showed that Gata4 has a role in cardiac angiogenesis. [4]

1. White RA, Dowler LL, Pasztor LM, Gatson LL, Adkison LR, Angeloni SV, Wilson DB (October 1995). "Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization)". Genomics 27 (1): 20-6. 2. Arceci, R. J., King, A. A., Simon, M. C., Orkin, S. H., Wilson, D. B. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Molec. Cell. Biol. 13: 2235-2246, 1993. 3. Köhler, B; Lin, L; Ferraz-De-Souza, B; Wieacker, P; Heidemann, P; Schröder, V; Biebermann, H; Schnabel, D et al. (2008). "Five novel mutations in steroidogenic factor 1 (SF1, NR5A1) in 46,XY patients with severe underandrogenization but without adrenal insufficiency". Human Mutation 29 (1): 59-64. 4. Heineke, J., Auger-Messier, M., Xu, J., Oka, T., Sargent, M. A., York, A., Klevitsky, R., Vaikunth, S., Duncan, S. A., Aronow, B. J., Robbins, J., Crombleholme, T. M., Molkentin, J. D. Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J. Clin. Invest. 117: 3198-3210, 2007. Note: Erratum: J. Clin. Invest. 118: 387 only, 2008.

Small volumes of anti-GATA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS355176 is an antibody targeting GATA4. Reactive in Human, mouse. Host: Rabbit.