Rabbit Anti-FOXD3 Polyclonal Antibody – Cat# MBS355177

Forkhead Box D3, FOXD3 (FOXD3) Antibody – Rabbit Polyclonal

Name: FOXD3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS355177
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS355177

Forkhead box D3 also known as FOXD3 is a forkhead protein that in humans is encoded by the FOXD3 gene.[1] This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Forkhead box D3, FOXD3, Polyclonal Antibody

Full Product Name

Anti-Forkhead box D3, FOXD3 antibody

Product Gene Name

anti-FOXD3 antibody

Product Synonym Names

Polyclonal Anti- Forkhead box D3; FOXD3

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid

Purity/Purification

Immunogen affinity purified

Preparation and Storage

Store at 4 degree C after thawing (1 week). Aliquot and store at -20 degree C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Molecular Weight

47,630 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (63788730..63790797). Location: 1p31.3

OMIM

607836

3D Structure

ModBase 3D Structure for Q9UJU5

Immunogen

A synthetic peptide (conjugated to KLH) corresponding to the region of human FOXD3.

Storage Buffer

In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

Applications Tested/Suitable for anti-FOXD3 antibody

Western Blot (WB)

Application Notes for anti-FOXD3 antibody

WB (1:1000)

Product References and Citations for anti-FOXD3 antibody

1. Hromas R, Moore J, Johnston T, Socha C, Klemsz M (June 1993). "Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells". Blood 81 (11): 2854-9. 2. Alkhateeb A, Fain PR, Spritz RA (August 2005). "Candidate functional promoter variant in the FOXD3 melanoblast developmental regulator gene in autosomal dominant vitiligo". J. Invest. Dermatol. 125 (2): 388-91.3. Hanna, L. A., Foreman, R. K., Tarasenko, I. A., Kessler, D. S., Labosky, P. A. Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev. 16: 2650-2661, 2002. 4. Guo, Y., Costa, R., Ramsey, H., Starnes, T., Vance, G., Robertson, K., Kelley, M., Reinbold, R., Scholer, H., Hromas, R. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate ectodermal-specific promoter expression. Proc. Nat. Acad. Sci. 99: 3663-3667, 2002.

Other Notes

Small volumes of anti-FOXD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOXD3 purchase

MBS355177 is an antibody targeting FOXD3. Also known as Anti-Forkhead box D3, FOXD3 antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FOXD3. It may not necessarily be applicable to this product.

NCBI GI #

6912372

NCBI GeneID

27022

NCBI Accession #

NP_036315.1

UniProt Primary Accession #

Q9UJU5

UniProt Secondary Accession #

Q9BYM2; Q9UDD1

UniProt Related Accession #

Q9UJU5

GenBank Nucleotide #

NM_012183.2

NCBI Official Full Name

forkhead box protein D3

NCBI Official Synonym Full Names

forkhead box D3

NCBI Official Symbol

FOXD3

NCBI Official Synonym Symbols

AIS1; HFH2; VAMAS2; Genesis

UniProt Protein Name

Forkhead box protein D3

UniProt Synonym Protein Names

HNF3/FH transcription factor genesis

Protein Family

Forkhead box protein

UniProt Gene Name

FOXD3

UniProt Synonym Gene Names

HFH2

UniProt Entry Name

FOXD3_HUMAN

NCBI Protein Information

forkhead box protein D3; HNF3/FH transcription factor genesis

NCBI Summary for FOXD3

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]

UniProt Comments for FOXD3

Function: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Ref.4

Subcellular location: Nucleus

Probable.

Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. Ref.3

Involvement in disease: Autoimmune disease 1 (AIS1) [MIM:607836]: An autoimmune disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis).Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.5

Sequence similarities: Contains 1 fork-head DNA-binding domain.

Research Articles on FOXD3

1. upregulation of ERBB3 is involved in melanoma adapting to RAF/MEK inhibitors through FOXD3

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FOXD3 antibody

Reference Product	PubMed Publications
NANOG antibody	>31 publications with FOXD3 and NANOG
SOX10 antibody	>25 publications with FOXD3 and SOX10
OCT4 antibody	>21 publications with FOXD3 and OCT4
SOX9 antibody	>20 publications with FOXD3 and SOX9
PAX3 antibody	>18 publications with FOXD3 and PAX3
MYF5 antibody	>3 publications with FOXD3 and MYF5
FOXC2 antibody	>1 publications with FOXD3 and FOXC2
NLRP1 antibody	>1 publications with FOXD3 and NLRP1

Pathways associated with anti-FOXD3 antibody

Products by Pathway	Pathway Diagram
Neural Crest Differentiation Pathway antibodies	Neural Crest Differentiation Pathway Diagram
Wnt Signaling Pathway And Pluripotency antibodies	Wnt Signaling Pathway And Pluripotency Diagram

Diseases associated with anti-FOXD3 antibody

Disease Name	Pubmed Publications
Abnormalities, Multiple Antibodies	>2 publications with FOXD3 and Abnormalities, Multiple
Sarcoma Antibodies	>2 publications with FOXD3 and Sarcoma
Ovarian Neoplasms Antibodies	>1 publications with FOXD3 and Ovarian Neoplasms
Heart Defects, Congenital Antibodies	>1 publications with FOXD3 and Heart Defects, Congenital
Necrosis Antibodies	>1 publications with FOXD3 and Necrosis
Respiratory Tract Diseases Antibodies	>1 publications with FOXD3 and Respiratory Tract Diseases
Prenatal Injuries Antibodies	>1 publications with FOXD3 and Prenatal Injuries
Prenatal Exposure Delayed Effects Antibodies	>1 publications with FOXD3 and Prenatal Exposure Delayed Effects
Abnormalities, Drug-Induced Antibodies	>1 publications with FOXD3 and Abnormalities, Drug-Induced
AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 1 Antibodies	>1 publications with FOXD3 and AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 1

Organs/Tissues associated with anti-FOXD3 antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>42 publications with FOXD3 and Embryonic Tissue
Eye Antibodies	>7 publications with FOXD3 and Eye
Intestine Antibodies	>3 publications with FOXD3 and Intestine
Heart Antibodies	>3 publications with FOXD3 and Heart
Ear Antibodies	>2 publications with FOXD3 and Ear
Kidney Antibodies	>2 publications with FOXD3 and Kidney