Neuropilin and Tolloid Like 1, NETO1 (NETO1) Antibody – Mouse Polyclonal

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Function: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory

By similarity.

Subunit structure: Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains

By similarity.

Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein

Potential. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density

By similarity. Note: Component of the postsynaptic density (PSD) of excitatory synapses

By similarity.Isoform 3: Cell membrane; Single-pass type I membrane protein

Potential. Isoform 1: Secreted

Potential.

Tissue specificity: Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain. Ref.1

Sequence similarities: Contains 2 CUB domains.Contains 1 LDL-receptor class A domain.