KGF Recombinant Protein

Recombinant human KGF protein with molecular weight 18.9 kDa.
The Keratinocyte Growth Factor (KGF), also known as FGF7, is a growth factor present in the epithelialization-phase of wound healing. KGF was both acid and heat labile and consisted of a single polypeptide chain of approximately 28 kDa. Lack of mitogenic activity on either fibroblasts or endothelial cells indicated that KGF possessed a target cell specificity distinct from any previously characterized growth factor. Microsequencing revealed an amino-terminal sequence containing no significant homology to any known protein. The release of this growth factor by human embryonic fibroblasts raises the possibility that KGF may play a role in mesenchymal stimulation of normal epithelial cell proliferation. FGF7 and FGF22 promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers. Terauchi et al. (2010) concluded that specific FGFs act as target-derived presynaptic organizers and help to organize specific presynaptic terminals in the mammalian brain.

1. Rubin, J. S., Osada, H., Finch, P. W., Taylor, W. G., Rudikoff, S., Aaronson, S. A. Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc. Nat. Acad. Sci. 86: 802-806, 1989. 2. Terauchi, A., Johnson-Venkatesh, E. M., Toth, A. B., Javed, D., Sutton, M. A., Umemori, H. Distinct FGFs promote differentiation of excitatory and inhibitory synapses. Nature 465: 783-787, 2010.

Small volumes of KGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS355571 is a recombinant protein targeting KGF. Also known as KGF, FGF7 Protein (Active). Host: E Coli.