Cytokeratin 20, CK20 (CK20) Recombinant Protein

Recombinant full length human Cytokeratin 20 protein with molecular weight 46.6 kDa.
Keratin 20, also called Cytokeratin 20, CK20, is a protein that in humans is encoded by the KRT20 gene. KRT20 has an apparent molecular mass of about 46 kD. It is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. KRT20 formed heterotypic complexes with KRT8 in vitro, and the complexes assembled into intermediate filaments under appropriate conditions. The protein is commonly found in colorectal cancer, transitional cell carcinomas and in Merkel cell tumours, but is absent in lung cancer, prostate cancer, and non-mucinous ovarian cancer. It is often used in combination with antibodies to CK7 to distinguish different types of glandular tumour.

1. Moll R, Schiller DL, Franke WW (August 1990). "Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns". J. Cell Biol. 111 (2): 567-80. 2. Moll, R., Schiller, D. L., Franke, W. W. Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. J. Cell Biol. 111: 567-580, 1990. 3. Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 171-172.

Small volumes of CK20 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS355586 is a recombinant protein targeting CK20. Also known as Cytokeratin 20, CK20 Protein (Active). Host: E Coli.