IL-5 Recombinant Protein

Recombinant human IL-5 protein with molecular weight 26.5 kDa.
Interleukin 5 (IL-5) is an interleukin produced by T helper-2 cells and mast cells. It is a 115-amino acid-long TH2 cytokine that is part of the hematopoietic family. It is expressed by eosinophils and has been observed in the mast cells of asthmatic airways by immunohistochemistry. IL-5 expression is regulated by several transcription factors including GATA3. IL-5 is a key mediator in eosinophil activation. It has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, where in a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease.

1. Dubucquoi S, Desreumaux P, Janin A, Klein O, Goldman M, Tavernier J et al. Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion. J Exp Med 1994; 179(2):703-708. 2. Kaminuma O, Mori A, Kitamura N, Hashimoto T, Kitamura F, Inokuma S et al. Role of GATA-3 in IL-5 gene transcription by CD4+ T cells of asthmatic patients. Int Arch Allergy Immunol 2005; 137 Suppl 1:55-9. Epub;%2005 Jun 2.:55-59. 3. Bradding P, Roberts JA, Britten KM, Montefort S, Djukanovic R, Mueller R et al. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994; 10(5):471-480. 4. Shen HH, Ochkur SI, McGarry MP, Crosby JR, Hines EM, Borchers MT et al. A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the Human. J Immunol 2003; 170(6):3296-3305.

Small volumes of IL-5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS355588 is a recombinant protein targeting IL-5. Also known as IL-5 Protein (Active). Host: E Coli.